Radiation Therapy in Treating Patients With Aggressive Fibromatoses
- Conditions
- Desmoid Tumor
- Registration Number
- NCT00030680
- Brief Summary
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells.
PURPOSE: Phase II trial to study the effectiveness of radiation therapy in treating patients who have aggressive fibromatoses.
- Detailed Description
OBJECTIVES:
* Determine the efficacy of moderate-dose radiotherapy, in terms of local control, in patients with aggressive fibromatoses.
* Determine the acute and late side-effects of this regimen in these patients.
OUTLINE: This is a multicenter study.
Patients receive radiotherapy 5 days a week for 5.5 weeks for a total of 56 Gy in 28 fractions.
Patients are followed every 3 months for 2 years and then every 6 months thereafter.
PROJECTED ACCRUAL: A total of 40 patients will be accrued for this study within 3 years.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 44
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Local control as assessed by MRI at 3 years
- Secondary Outcome Measures
Name Time Method Toxicity as assessed by CTC 2.0 Response as assessed by MRI
Trial Locations
- Locations (21)
Cliniques Universitaires Saint-Luc
🇧🇪Brussels, Belgium
Leiden University Medical Center
🇳🇱Leiden, Netherlands
Daniel Den Hoed Cancer Center at Erasmus Medical Center
🇳🇱Rotterdam, Netherlands
Maastro Clinic - Locatie Maastricht
🇳🇱Maastricht, Netherlands
University Medical Center Groningen
🇳🇱Groningen, Netherlands
Centre Leon Berard
🇫🇷Lyon, France
Cookridge Hospital
🇬🇧Leeds, England, United Kingdom
Christie Hospital
🇬🇧Manchester, England, United Kingdom
Universitair Ziekenhuis Antwerpen
🇧🇪Edegem, Belgium
Arnhems Radiotherapeutisch Instituut
🇳🇱Arnhem, Netherlands
Institut Bergonie
🇫🇷Bordeaux, France
CHU de la Timone
🇫🇷Marseille, France
Southwest German Cancer Center at Eberhard-Karls-University
🇩🇪Tuebingen, Germany
Dr. Bernard Verbeeten Instituut
🇳🇱Tilburg, Netherlands
Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology
🇵🇱Warsaw, Poland
Mount Vernon Cancer Centre at Mount Vernon Hospital
🇬🇧Northwood, England, United Kingdom
Centre Hospitalier Universitaire Vaudois
🇨ðŸ‡Lausanne, Switzerland
Queen Elizabeth Hospital at University Hospital of Birmingham NHS Trust
🇬🇧Birmingham, England, United Kingdom
Nottingham City Hospital NHS Trust
🇬🇧Nottingham, England, United Kingdom
Cancer Research Centre at Weston Park Hospital
🇬🇧Sheffield, England, United Kingdom
Royal Marsden - Surrey
🇬🇧Sutton, England, United Kingdom