Safety evaluation and clinical anticandidal and antibacterial efficacy of coconut oil mouthwash formulation in older adults.

Phase 2

Recruiting

• Conditions: Candida and bacterial counts in older adults; candida ,bacterial, oral rinse , virgin coconut oil

• Registration Number: TCTR20240711004
• Lead Sponsor: Faculty of Dentistry, Chiangmai University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2024-07-01
• Study Start: 2024-07-11
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

1. Aged 60 years and older, classified as ASA (American Society of Anesthesiologists) 1-3.
2. Independent older adults who can perform oral rinsing independently.
3. Candida spp. found through concentrated oral rinse culture, with a quantity not exceeding 600 cfu/ml

Exclusion Criteria

1. History of allergy to coconut oil, chlorhexidine mouthwash, or other components used in this research.
2. Symptoms of oral candidiasis
3. Smokers or quit smoking less than 1 year ago.
4. Experiences difficulty swallowing (dysphagia).
5. Cognitive impairment and abnormal brain function affecting communication and cooperation.
History of using specific or systemic antifungal medications within 1 month before participating in the research.
6. Not willing to participate in the research project.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Reduction in the quantity of Candida and overall bacteria. at 2 weeks after the intervention CFU/ml

Secondary Outcome Measures

Name	Time	Method
Patients' satisfaction at 2 weeks after the intervention Patient reported outcome using a questionnaire interview