Changes in Intestinal Microbiota and Acquisition of Antimicrobial Resistance in Hong Kong Residents After Travel
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 125
- 试验地点
- 1
- 主要终点
- Proportion of patients acquiring intestinal colonization of ESBL-producing Enterobacteriaceae
研究概览
简要总结
International travel is well reported to be associated with acquisition of multidrug-resistant organisms, however, the impact of colonization of these multidrug-resistant organisms is currently uncertain. As colonization of multidrug-resistant organisms had been demonstrated to be associated with distinct intestinal microbiota composition and travellers constitute a generally healthy population with minimal antibiotics exposure; by evaluating serial stool samples before and after travel, the investigators can delineate a potential causal relationship between host intestinal microbiota and subsequent risk of acquisition of multidrug-resistant organisms.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged 18 years or above
- •Chinese ethnicity
- •Planning to visit any places outside of Hong Kong within the next three months
- •Able to provide informed consent
排除标准
- •Use of antibiotics within 4 weeks prior to the time of recruitment (Except for antimalarial prophylaxis)
- •Hospitalization within 3 months
- •Underlying gastrointestinal diseases, including gastrointestinal malignancy, inflammatory bowel disease, resection of small or large bowel
- •Pregnancy
结局指标
主要结局
Proportion of patients acquiring intestinal colonization of ESBL-producing Enterobacteriaceae
时间窗: 1 year
Intestinal colonization of ESBL-producing Enterobacteriaceae is defined as the presence of ESBL in Enterobacteriaceae identified in the post-travel stool samples, in patients without these organisms detected in their stool samples before travel.
次要结局
- Proportion of patients acquiring intestinal colonization of carbapenem-resistant Enterobacteriaceae(1 year)
研究者
Grace Lui
Assistant Professor
Chinese University of Hong Kong