Effect of Accelerated Pacing Rates on Exercise Tolerance, Quality of Life and Arrhythmia Burden in Patients with Evidence of Heart Failure with Preserved Ejection Fraction: The PACE-UP Randomised Controlled Trial

niversity of Adelaide0 个研究点目标入组 160 人开始时间: 2023年11月17日最近更新: 2024年4月8日

适应症

试验速览

暂无简介。

•Adults 18-80 years old with a pacemaker.
•Preclinical or clinical heart failure with preserved ejection fraction according to the diagnostic criteria of the HFA of the ESC.
•Sinus node dysfunction with intact AV node conduction or minimal RV pacing (<20%) and paced QRS <150ms.
•Impaired AV node conduction with His bundle or left bundle branch area pacing, or biventricular pacing.
•Subject is expected to remain available for follow-up visits.

•Left ventricular ejection fraction <45%.
•Inability to participate in exercise testing due to musculoskeletal disease or other active diseases.
•Myocardial infarction within the past 12 months.
•Infiltrative cardiomyopathy.
•Hypertrophic cardiomyopathy.
•More than moderate valvular stenosis or regurgitation.
•Aortic valve replacement in the past one year.
•Significant primary pulmonary disease on home oxygen.
•Uncontrolled hypertension as defined by BP >160/100 mmHg on two measurements >15 minutes apart.

发起方

niversity of Adelaide