Effect of Accelerated Pacing Rates on Exercise Tolerance, Quality of Life and Arrhythmia Burden in Patients with Evidence of Heart Failure with Preserved Ejection Fractio

Not Applicable

Recruiting

• Conditions: Heart failure with preserved ejection fraction; Sinus Node Disease; Cardiovascular - Other cardiovascular diseases

• Registration Number: ACTRN12623001187639
• Lead Sponsor: niversity of Adelaide

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-11-17
• Last Update Posted: 8 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

•Adults 18-80 years old with a pacemaker.
•Preclinical or clinical heart failure with preserved ejection fraction according to the diagnostic criteria of the HFA of the ESC.
•Sinus node dysfunction with intact AV node conduction or minimal RV pacing (<20%) and paced QRS <150ms.

OR

•Impaired AV node conduction with His bundle or left bundle branch area pacing, or biventricular pacing.
•Subject is expected to remain available for follow-up visits.

Exclusion Criteria

•Left ventricular ejection fraction <45%.
•Inability to participate in exercise testing due to musculoskeletal disease or other active diseases.
•Myocardial infarction within the past 12 months.
•Infiltrative cardiomyopathy.
•Hypertrophic cardiomyopathy.
•More than moderate valvular stenosis or regurgitation.
•Aortic valve replacement in the past one year.
•Significant primary pulmonary disease on home oxygen.
•Uncontrolled hypertension as defined by BP >160/100 mmHg on two measurements >15 minutes apart.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Peak oxygen consumption (VO2peak).[Cardiopulmonary exercise testing on an upright cycle ergometer, recorded by a metabolic cart. Baseline and 52-weeks post-randomisation. ]