The effect of administration of terlipressine in the cervix of the uterus on the amount of uptake of fluid, formation of gas bubbles and the circulation during hysteroscopy
Recruiting
- Conditions
- <p>myoma. menorrhagia</p>
- Registration Number
- NL-OMON28576
- Lead Sponsor
- .E. OverdijkOLVG, Oosterpark 9, 1091 AC Amsterdam, l.e.overdijk@olvg.nl, 020-599111
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 48
Inclusion Criteria
48 patiens (ASA classification 1 or 2) secheduled for trans cervical resection of large type 1-2 moma's (TCR-M) or extensive trans cervical endometrium resection (TCR-E)
Exclusion Criteria
Trans cervical operations of small myoma's and minor TCR-E procedures.
Short lasting procedures of < 1/2 hour.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>to determine whether the intracervical insallation of terlipressin reduces the inncidence and severity of gas embolsim as detected by trans oesophageal echocardiography (TOE)</p>
- Secondary Outcome Measures
Name Time Method <p>to study the effect of intracervical terlipressin on the amont of intravasation, global hemodynamics, myocardial ventricular systolic strain and myocardial diastolic funcion using TOE. A substudy will be done analysing the laboratoy results to determine elceltrlyte changes and assessing acid-base disturbances.</p>