Prospective long-term study of central neuronal activity in single-sided deaf patients before and after cochlear implantatio

Recruiting

Conditions: H90.4
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side

Registration Number: DRKS00023011

Lead Sponsor: HNO-Uniklinik Freiburg

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 63

Inclusion Criteria

Hearing ability of the poorer ear: profound hearing loss up to deafness; monosyllable understanding in the Freiburg monosyllable test at 65 dB of less than 50% with a hearing aid; hearing ability of the better ear: air conduction hearing threshold up to and including 4 kHz = 30 dB HL; difference between the worse and better ear of = 30 dB; CI indication

Exclusion Criteria

Age < 18 years and > 65 years;
Understanding of the German language at least at B1 level;
left-handed;
relevant neurological or psychiatric concomitant disease;
relevant ophthalmologic diseases;
circumstances and diseases which are a contraindication for MRI or which indicate insufficient compliance with the fMRI examination; circumstances and diseases that indicate or are likely to indicate inadequate compliance with the PET examination;
Pregnancy, breastfeeding, current desire to have children;
persons unable to give consent

Study & Design

Study Type: observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
How does central nervous activity in the auditory pathway changes when SSD patients are fitted with a CI using PET/CT 6 months and 5 years after CI fitting?

Secondary Outcome Measures

Name	Time	Method
(I) How does audiological performance change when fitting SSD patients with a CI?<br>(II) How does visual perception change when SSD patients are fitted with a CI?<br>(III) How does somatosensory perception change when SSD patients are fitted with a CI?<br>(IV) How does cognitive ability change when SSD patients are fitted with a CI?<br>(V) How does central nervous processing auditory, visual, and somatosensory stimuli differ between normal hearing and SSD patients?