Effectiveness of Low-dose Aspirin in Gastrointestinal Cancer Prevention - Hong Kong
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Bayer
- 入组人数
- 99,999
- 试验地点
- 1
- 主要终点
- Incidence rate ratio of colorectal cancer among users of low-dose-aspirin (exposed) and users of paracetamol monotherapy (non-exposed)
研究概览
简要总结
In this study, researchers wanted to learn more about the effect of Aspirin taken as low dose (75 - 300 mg) in preventing stomach, colorectal and esophagus cancer. The researchers were interested in the effect by duration of aspirin use and the effect on the time since aspirin intake has been stopped in preventing stomach, colorectal and esophagus cancer. In addition, the study also looked into the time patients survived after being diagnosed (survival rate) with cancer and number of cancer patients who died (case fatality rate). The study was based on an electronic database managed by the Health Authority in Hong Kong containing anonymized clinical information of patients living in Hong Kong.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Received prescription of either low-dose aspirin (75-300 mg) or paracetamol monotherapy during enrolment period.
排除标准
- •Received prescription of aspirin monotherapy or combination one year prior to the index date
- •Recorded diagnoses of any type of cancer before the index date
- •Recorded procedures of colectomy, gastrectomy prior to the index date
- •Age < 40 years
研究组 & 干预措施
New-users of Low-dose aspirin (exposed group)
New-users of low-dose aspirin is defined as patients who did not receive any prescriptions of low-dose aspirin one year prior to the index date.
干预措施: Acetylsalicylic Acid (Aspirin, BAYE4465) (Drug)
结局指标
主要结局
Incidence rate ratio of colorectal cancer among users of low-dose-aspirin (exposed) and users of paracetamol monotherapy (non-exposed)
时间窗: Retrospective analysis between 1st January 2004 and 31st December 2008
Ratio of incidence (per 10,000 person years) among users of low-dose-aspirin (exposed) and users of paracetamol monotherapy (non-exposed)
Incidence rate ratio of gastric cancer among users of low-dose-aspirin (exposed) and users of paracetamol monotherapy (non-exposed)
时间窗: Retrospective analysis between 1st January 2004 and 31st December 2008
Ratio of incidence (per 10,000 person years) among users of low-dose-aspirin (exposed) and users of paracetamol monotherapy (non-exposed)
Incidence rate ratio of esophageal cancer among users of low-dose-aspirin (exposed) and users of paracetamol monotherapy (non-exposed)
时间窗: Retrospective analysis between 1st January 2004 and 31st December 2008
Ratio of incidence (per 10,000 person years) among users of low-dose-aspirin (exposed) and users of paracetamol monotherapy (non-exposed)
次要结局
- Duration of aspirin use(Retrospective analysis between 1st January 2004 and 31st December 2008)
- Risk of colorectal, gastric and esophageal cancer after discontinuation of aspirin use(Retrospective analysis between 1st January 2004 and 31st December 2008)
- Case-fatality and survival rate(Retrospective analysis between 1st January 2004 and 31st December 2008)