The Effect of Brachial Plexus Nerve Block on Distal Peripheral Nerve Conduction

Withdrawn

• Conditions: Anesthesia

• Registration Number: NCT01716078
• Lead Sponsor: Defense and Veterans Center for Integrative Pain Management

Brief Summary

The purpose of this study is to determine the conducting ability of distal extremity nerves after a supraclavicular brachial plexus nerve block (with local anesthetic) has been placed at a more proximal location in the upper extremity.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-11
• Study First Submitted: 2012-10-17
• Study First Submitted QC: 2012-10-25
• Study First Posted: 2012-10-29
• Primary Completion: 2014-09
• Status Verified: 2016-01
• Last Update Submitted: 2016-01-28
• Last Update Posted: 2016-01-29

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Male and female military health care beneficiaries 18 years and older, capable of providing informed consent indicating awareness of the investigational nature of the study, in keeping with institutional policy
• Written informed consent must be obtained from each patient prior to entering the study
• Patients must be willing to have a regional anesthetic nerve block placed prior to their scheduled procedure
• Patients must be willing to have neurodiagnostic tests performed prior to placement and after placement of the regional anesthesia nerve block

Exclusion Criteria

• Refusal to have a brachial plexus nerve block placed
• Refusal to have serial nerve conduction studies performed
• Contraindication for a regional anesthesia nerve block (allergy to local anesthetic, infection at site of injection, elevated coagulation time)
• Presence of conditions affecting the hand or arm (e.g., injury, infection) that might preclude the performance of nerve conduction studies
• Presence of known major abnormalities of nerve conduction, e.g., absent median sensory potential in a patient scheduled for carpal tunnel release
• Presence of conditions affecting the contralateral hand or arm (e.g., injury, infection) that might preclude the performance of sensory and motor studies to test block or absence of a contralateral upper extremity

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Compund Muscle Action Potential (CMAP) amplitude	1 day	measured for motor studies from baseline to peak in mV

Secondary Outcome Measures

Name	Time	Method
Distal Latency	1 day	the interval between the stimulation of a compound muscle and the observed response. Normal nerve conduction velocity is above 40 m/sec in the lower extremities and above 50 m/sec in the upper extremities, but age, muscle disease, temperature, and other factors can influence the velocity.
Peak Latency	1 day	* This represents conduction along the majority of the axons; * It is recorded at the peak of the waveform response
Onset Latency	1 day	* This represents conduction along the fastest axons; * It is recorded at the initial deflection from baseline

Trial Locations

Locations (1)

Fort Meade; 🇺🇸 Fort Meade, Maryland, United States