Effectiveness of Low-Level Laser Therapy and Topical Steroid Therapy in the Management of Oral Lichen Planus
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- The erosion size
研究概览
简要总结
The goal of applications of Low-Level Laser and Topical Steroid in the Management of Oral Lichen Planus is to learn if intervention can by relieve pain, decreasing inflammation, and facilitating tissue healing in20 patients who were suffering from erosive oral lichen planus. The main questions it aims to answer are which is better and more effective as treatment modality. The erosion size (mm2) measured on the first day and 4 weeks later. Oral Health-Related Quality of Life questionnaire manipulated. Researchers will take Low-Level Laser and Topical Steroid in the Management of Oral Lichen Planus to see if it could be used as separate treatment option or as combination.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Investigator, Outcomes Assessor)
盲法说明
Out of all the researchers, only one had knowledge of the patients' assigned groups. Neither the therapies nor their efficacy was evaluated by this unblinded researcher. There was a lack of treatment blinding for patients.
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients who were monitored for OLP.
- •clinical and histopathological finding of OLP in accordance with van der Meij
- •being over 18 years old.
排除标准
- •Patients with systemic disorders, pregnancy, using drugs, smoking, lesions in contact with dental amalgams, and cutaneous or other mucosal involvement at the time of treatment were excluded.
研究组 & 干预措施
Topical Steroid Therapy of Erosive oral lichen planus
topical application of 0.1% triamcinolone acetonide and photo biomodulation on erosive oral lichen planus, 3 times daily and a miconazole oral gel once daily, for 4 weeks
干预措施: 0.1% topical triamcinolone Acetonide preparation "Kenacourt-A Orabase" (Drug)
Low-Level Laser Therapy of Erosive oral lichen planus
Photo biomodulation with laser therapy twice a week for 8 sessions over 4 weeks, utilizing a 980 nm diode laser with an output power of 300 mw.
干预措施: 980 nm diode laser (Device)
结局指标
主要结局
The erosion size
时间窗: From enrollment to the end of treatment at 4 weeks"
The maximal diameter (mm) and width (mm) were measured perpendicularly using a calibrated periodontal probe
The Visual Analogue Scale (VAS)
时间窗: From enrollment to the end of treatment at 4 weeks"
pain ratings span from zero (indicating the absence of pain) to 10 (representing extremely intense pain) along a horizontal line values. { the minimum is 0 and maximum is 10 }
次要结局
- Oral Health-Related Quality of Life (OHRQoL)(From enrollment to the end of treatment at 4 weeks")
研究者
Asem Mohammed Kamel Ali
Director
Al-Azhar University