Neutralizing Antibody Level After COVID-19 Vaccination

Recruiting

• Conditions: Covid19

• Registration Number: NCT05083026
• Lead Sponsor: Kyungpook National University Hospital

Brief Summary

1. serial of neutralizing antibody at 2, 4, 6, 9, 12 month after COVID-19 vaccination

2. investigate the factors on antibody titer.

Detailed Description

1. serial of neutralizing antibody at 2, 4, 6, 9, 12 month after COVID-19 vaccination 1) semi-quantitative measurement of neutralizing antibody at 2, 4, 6, 9, 12 month after COVID-19 vaccination 2) investigate the duration maintaining acceptable range (over 30% inhibition)

2. investigate the factors on antibody titer at 2 month after vaccination 1) potential factors: age, sex, body weight, height, use of medication, use of antipyretics (NSAID or tyrenol), side effect of COVID-19 vaccination 2) correlation between antibody titer and potential factors

3. Compare 4 diagnostic ELISA kit at 2 month after vaccination 1) measure neutralizung antibody using ELISA kits from 4 different companies 2) investigate correlation coefficient of antibody titer between companies

Study Timeline

• Study Start: 2021-06-02
• Study First Submitted: 2021-08-08
• Study First Submitted QC: 2021-10-18
• Study First Posted: 2021-10-19
• Status Verified: 2023-10
• Last Update Submitted: 2023-10-03
• Last Update Posted: 2023-10-04
• Primary Completion: 2024-12-31
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 51

Inclusion Criteria

• healthcare works after completion of COVID-19 vaccination
• 20-60 years
• sign the agreement of study

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Exclusion Criteria

• serious underlying diseases

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
titer of neutralizing antibody after COVID-19 vaccination	at 12 month after COVID-19 vaccination	semi-quantitative measurement of neutralizing antibody after COVID-19 vaccination
Compare 4 diagnostic ELISA kit after COVID-19 vaccination	at 2 month after COVID-19 vaccination	1. measure neutralizung antibody using ELISA kits from 4 different companies 2 months after COVID-19 vaccination; 2. investigate correlation coefficient of antibody titer between companies
body weight (Kg)	at 2 month after COVID-19 vaccination	correlation between antibody titer and body weight: spearmann's correlation
body mass index (kg/m^2)	at 2 month after COVID-19 vaccination	correlation between antibody titer and body weight: spearmann's correlation

Trial Locations

Locations (1)

Kyungpook National University Hospital; 🇰🇷 Daegu, Korea, Republic of