Intraocular Pressure and Ocular Perfusion Pressure of Cosopt in Normal Tension Glaucoma
- Conditions
- Normal Tension Glaucoma
- Interventions
- Drug: dorzolamide/timolol
- Registration Number
- NCT01175902
- Lead Sponsor
- The Catholic University of Korea
- Brief Summary
To prove the non-inferiority of the fixed timolol-dorzolamide combination (Cosopt) compared to 0.005% latanoprost (Xalatan) in the aspects of intraocular pressure (IOP) and ocular perfusion pressure (OPP) in subjects with normal tension glaucoma (NTG)
Clinical hypotheses. Primary hypothesis
* Cosopt group is non-inferior to Xalatan group in diurnal IOP reduction.
Secondary hypothesis
* Cosopt group is non-inferior to Xalatan group in diurnal diastolic and systolic OPP.
- Detailed Description
Cosopt (dorzolamide/timolol fixed combination) has well known effect for IOP reduction in POAG and OHT.3-5 However, there is no study about the effect and safety of Cosopt in NTG, Cosopt is not used the first line drug in the management of NTG.
In Korea, the prevalence of NTG is higher than western countries, the majority (about 80-90%) of open angle glaucoma patients have an IOP of 21 mmHg or less, so the study of NTG is important and searching of effective drug for the treatment of NTG is necessary.
In this study, we would prove the non-inferiority of Cosopt compared to Xalatan,6 which is used as a first line drug in the management of NTG, in the aspects of IOP and OPP including diastolic OPP (DOPP).
A prospective, interventional, randomized, crossover, single masked, single center study. Forty-four NTG patients were randomly allocated to one of two groups. Patients in group A were treated with Cosopt, lubricant, and Xalatan for 4 weeks each, whereas patients in group B were treated with Xalatan, lubricant, and Cosopt for 4 weeks each.
Recruit NTG patients, who are not treated with the glaucoma medication recent 2 months. If treated, after washout period of 4 weeks, the patients can be included in the study. Baseline IOP, systolic and diastolic BP will be measured. (Day 1) After 4 weeks of treatment of Cosopt or Xalatan, all participants will be checked diurnal IOP, systolic and diastolic BP. IOP was measured by Goldmann applanation tonometry (mean of three consecutive readings) with the patient in a sitting position at the slit lamp. Every IOP will be measured by one masked glaucoma specialist who is unaware of the treatment assignments. After the IOP measurements, after a 5-minite rest, pulse rate and BP (systolic and diastolic) of radial artery were measured in the sitting position using a standard automated blood pressure cuff. During the period, all measuring instruments keep to be calibrated by the manufacturer's instruction.
- OPP was calculated according to the following formula: OPP=(1/3 systolic BP + 2/3 diastolic BP) x 2/3 -IOP, diastolic OPP (DOPP)=diastolic BP-IOP. During the 4 weeks washout period, subjects will use lubricants.(Week 8) In this crossover study, with the other eye drops, the same measurement will be performed. (Week 12)
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 44
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Arm 1 dorzolamide/timolol Latanoprost first, then Dorzolamide/Timolol Patients first on Latanoprost eyedrops once a day, then on Dorzolamide/Timolol twice a day Arm 2 dorzolamide/timolol Dorzolamide/Timolol first, then Latanoprost Patients first on Dorzolamide/Timolol eyedrops twice a day, then on Latanoprost eyedrops once a day Arm 2 latanoprost Dorzolamide/Timolol first, then Latanoprost Patients first on Dorzolamide/Timolol eyedrops twice a day, then on Latanoprost eyedrops once a day Arm 1 latanoprost Latanoprost first, then Dorzolamide/Timolol Patients first on Latanoprost eyedrops once a day, then on Dorzolamide/Timolol twice a day
- Primary Outcome Measures
Name Time Method Intraocular Pressure (IOP), Period 1 4 weeks IOP (mean IOP) after 4 weeks of treatment
Intraocular Pressure (IOP), Period 2 12 weeks IOP (mean IOP) after treaemt from week 8 to week 12
Blood Pressure (BP), Period 1 4 weeks systolic and diastolic BP at 4 weeks after use of eyedrops
Blood Pressure (BP), Period 2 12 weeks systolic and diastolic BP measured after treaemt from week 8 to week 12
- Secondary Outcome Measures
Name Time Method Ocular Perfusion Pressure (OPP), Period 1 4 weeks OPP was calculated according to the following formula:
OPP=(1/3 systolic BP + 2/3 diastolic BP) x 2/3 -IOP, diastolic OPP (DOPP)=diastolic BP-IOPOPP, Period 2 12 weeks OPP was calculated according to the following formula:
OPP=(1/3 systolic BP + 2/3 diastolic BP) x 2/3 -IOP, diastolic OPP (DOPP)=diastolic BP-IOP
OPP after treaemt from week 8 to week 12
Trial Locations
- Locations (1)
Seoul St. Mary's hospital
🇰🇷Seoul, Korea, Republic of