British orthopaedic surgery surveillance study

Not Applicable

Completed

• Conditions: Slipped capital femoral epiphysis (SCFE), Perthes' disease; 1. Slipped Capital Femoral Epiphysis (SCFE) 2. Perthes' disease; Musculoskeletal Diseases

• Registration Number: ISRCTN54477575
• Lead Sponsor: niversity of Liverpool

Brief Summary

2020 Protocol article in https://doi.org/10.1302/2046-3758.13.BJO-2020-0002 SCFE protocol (added 12/05/2020) 2020 Protocol article in https://doi.org/10.1302/2046-3758.13.BJO-2020-0008 protocol (added 12/05/2020) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35360941/ Perthes' disease epidemiology and two-year outcomes (added 04/04/2022) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35360942/ slipped capital femoral epiphysis epidemiology and two-year outcomes (added 04/04/2022)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-04-19
• Study Completion: 2020-03-01
• Last Update Posted: 19 April 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 857

Inclusion Criteria

SCFE:
1.Skeletally immature individuals
2. Radiological confirmation of displacement of the epiphysis relative to the metaphysis occurring at the proximal femoral physis
3. Newly presenting to secondary/ tertiary care during the study period with the above radiographic changes in either hip (i.e. patients will be included if the other side has been affected outside the study period, but the opposite hip is newly affected)
4. Undergoing surgical stabilisation during hospital admission
5. Resident within the England, Scotland or Wales

Perthes:
1. Skeletally immature individuals.
2. Any of the following radiographic features within the femoral epiphysis. Features may be evident on plain radiographs, or MRI.
2.1. Flattening
2.2. Sclerosis
2.3. Fragmentation
2.4. Collapse
2.5. Reossification
3. Newly presenting to secondary/ tertiary care during the study period with the above radiographic changes in either hip (i.e. patients will be included if the other side has been affected outside the study period, but the opposite hip is newly affected)
4. Usually resident within the England, Scotland or Wales

Exclusion Criteria

SCFE:
Previous attempts at stabilisation of the currently affected hip.

Perthes:
1. Previous treatment for developmental hip dysplasia (not including double nappies)
2. Previous chemotherapy for malignancy
3. Previously diagnosed sickle cell anaemia
4. Multiple Epiphyseal Dysplasia (MED) or Spondyloepiphyseal Dysplasia (SED).
5. A known coagulopathy
6. Gauchers disease
7. Previous same-sided hip fracture
8. Hypothyroidism

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> Anonymised Surveillance Cohort:<br> Incidence of each disease within the UK is determined by expressing the cases seen as a proportion of the ‘at risk’ population. The ‘at risk’ population will be derived from government statistics. In order to ensure that the data collection mechanism is sensitive, a national independent network of orthopaedic surgical trainees (the BONE collaborative), and national routine administrative data provided by HSCIC is used to identify missing cases, and prompt their imputation into the cohort.<br><br> Nested Consented Cohort<br> Quality of Life is measured using the Pediatric Quality of Life Inventory (PEDSQL) at baseline, 3 months (SCFE only), 1 year (Perthes’ disease only) and 2 years (both diseases).<br>