Investigating childhood hip diseases (Slipped capital femoral epiphysis and Perthes’ disease) as childhood precursors to osteoarthritis of the hip in adulthood: A nationwide anonymised surveillance cohort, and nested-consented cohort study

niversity of Liverpool0 个研究点目标入组 857 人开始时间: 2017年4月19日最近更新: 2022年4月19日

适应症

试验速览

2020 Protocol article in https://doi.org/10.1302/2046-3758.13.BJO-2020-0002 SCFE protocol (added 12/05/2020) 2020 Protocol article in https://doi.org/10.1302/2046-3758.13.BJO-2020-0008 protocol (added 12/05/2020) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35360941/ Perthes' disease epidemiology and two-year outcomes (added 04/04/2022) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35360942/ slipped capital femoral epiphysis epidemiology and two-year outcomes (added 04/04/2022)

•1.Skeletally immature individuals
•2. Radiological confirmation of displacement of the epiphysis relative to the metaphysis occurring at the proximal femoral physis
•3. Newly presenting to secondary/ tertiary care during the study period with the above radiographic changes in either hip (i.e. patients will be included if the other side has been affected outside the study period, but the opposite hip is newly affected)
•4. Undergoing surgical stabilisation during hospital admission
•5. Resident within the England, Scotland or Wales
•1. Skeletally immature individuals.
•2. Any of the following radiographic features within the femoral epiphysis. Features may be evident on plain radiographs, or MRI.
•2.1. Flattening
•2.2. Sclerosis
•2.3. Fragmentation
•2.4. Collapse
•2.5. Reossification
•3. Newly presenting to secondary/ tertiary care during the study period with the above radiographic changes in either hip (i.e. patients will be included if the other side has been affected outside the study period, but the opposite hip is newly affected)
•4. Usually resident within the England, Scotland or Wales

•Previous attempts at stabilisation of the currently affected hip.
•1. Previous treatment for developmental hip dysplasia (not including double nappies)
•2. Previous chemotherapy for malignancy
•3. Previously diagnosed sickle cell anaemia
•4. Multiple Epiphyseal Dysplasia (MED) or Spondyloepiphyseal Dysplasia (SED).
•5. A known coagulopathy
•6. Gauchers disease
•7. Previous same-sided hip fracture
•8. Hypothyroidism

发起方

niversity of Liverpool