Comparison of Serum HDL, Serum Creatinine, Serum C-reactive protein as predictors of severity in sepsis.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- The SOFA Score of patients who survives will be low and those who do not survive the score
研究概览
简要总结
“Comaparison of serum HDL, serum Creatinine, serum C-reactive protein as predictors of severity in sepsis †is a prospective, observational study, that will be conducted in the surgical ICU of Calcutta
National Medical College and Hospital involving 40 sepsis patients. The severity of the
illness will be scored by SOFA score. Serum HDL, serum creatinine , serum CRP levels and
the variables required for SOFA score will be measured at four intervals ,at the time of
admission in intensive care unit i.e. day one, on day three, on day five and on day seven. The
correlation between SOFA scores and serum HDL, serum creatinine and serum CRP levels
will be assessed. All the three parameters in this study will help in determining the disease progression in the patient so that prompt action can be taken in appropriate time to alter the course of disease
with treatment modifications if possible, depending upon the patient’s clinical condition.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 70.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients with age greater than 18 years and satisfying the criteria for sepsis according to International guidelines for management of severe sepsis and septic shock.
排除标准
- •Patients on treatment with statins.
- •Patients with chronic kidney disease, chronic liver disease, thyroid dysfunction, diabetes mellitus, and malabsorption disorders.
- •Patients with known chronic infective and inflammatory conditions like Human immunodeficiency virus disease, SLE(Systemic lupus erythematous) and RA( Rheumatoid arthritis).
结局指标
主要结局
The SOFA Score of patients who survives will be low and those who do not survive the score
时间窗: Twelve months
will be high. The three parameters may show the following outcomes:
时间窗: Twelve months
(i)The serum HDL-cholesterol values may be low in non survivors and may be high or within
时间窗: Twelve months
normal limits among the survivors.
时间窗: Twelve months
(ii)The serum CRP values are likely to be high among the non survivors and low among the
时间窗: Twelve months
non survivors.
时间窗: Twelve months
(iii)The serum creatinine levels are likely to be high in patients who will be progressing
时间窗: Twelve months
towards septic shock and MODS and finally death.
时间窗: Twelve months
次要结局
- All the three parameters in this study i.e. serum HDL, serum Creatinine, serum C- reactive protein will help in determining the disease progression in the(patient so that prompt action can be taken in appropriate time to alter the course of disease)
研究者
Shivangi Singh
Calcutta National Medical College and Hospital