Efficacy and safety of G-Amrita formulation in the management of high uric acid and gouty arthritis

Many plant extracts and herbs have been used in the treatment and management  of Gout and hyperuricemia since long. Out of these plants, Tinospora cordifolia, Terminalia Chebula, Embica officinalis, Terminalia Bellirica and Tribulus terresteris have been chosen to form formulation for Gout and Hyper uricemia. These contains compounds with anti-prolferative, anti-oxidant, anti-inflammatory activities and is known to help in the management of Gout treatment. Tinospora cordifolia is immensely useful due to the presence of different compounds of pharmaceutical significance belonging to various groups such as alkaloids, diterpenoid lactones, glycosides, steroids, sesquiterpenoids, and phenolics. These compounds possess pharmacological properties, which make it anti-diabetic, antipyretic, antiinflammatory, anti-oxidant, hepato-protective, and immuno-modulatory [6].  T. chebula is supposed to have a significant quantity of gallic acid, ellagic acid, tannic acid, β-sitosterol, ethyl gallate, chebulic acid, ascorbic acid, and mannitol, which are responsible for its various pharmacological properties. In one study, it was seen that in addition to possessing superoxide radical scavenging activity (7]. T. bellerica  also inhibited uric acid formation, which was indicative of its XO enzyme inhibitory activity. Tribulus terrestris is a natural herb, also known as Puncture vine or Gokhru, used for treating several diseases and found in many tropical and moderate areas of the world, including the US and Mexico, Mediterranean region, and throughout Asia. T. terrestris is aphrodisiac, antihypertensive, diuretic, and antiurolithiatic in nature T. terrestris significantly reduced the excretion of oxalate, calcium, and phosphate along with decreased levels of blood urea nitrogen, uric acid and creatinine in serum. T. terrestris also reduced hyperoxaluria- caused oxidative stress, and restored antioxidant enzyme activity and their expression profile in kidney tissue. Emblica possess a vast ethno medical history and represents a phytochemical reservoir of heuristic medicinal value. It has been suggested in the scientific literature that consumption of it alleviates arthritic pain and Gout. Many pharmacological studies have shown that this plant extracts having antioxidant, anticarcinogenic, antitumor, antigenotoxic, antigout, and anti-inflammatory activities, and supporting its traditional uses.

Keeping such benefits in view, it was aimed to study effectiveness and safety profile of G -AMRITA in patients with hyper uricemia and /or Gout