Sleep Disordered Breathing in Children: Inflammation and Oxidative Stress

• Conditions: Sleep Disordered Breathing (SDB); Endothelial Dysfunction

• Registration Number: NCT02040701
• Lead Sponsor: Tel-Aviv Sourasky Medical Center

Brief Summary

The purpose of the study is to measure markers of inflammatory and oxidative stress known to be associated with cardiovascular morbidity in snoring children.

In addition, to measure markers of local inflammation and to evaluate the response to treatment.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-05
• Status Verified: 2014-01
• Study First Submitted: 2014-01-09
• Study First Submitted QC: 2014-01-15
• Last Update Submitted: 2014-01-15
• Study First Posted: 2014-01-20
• Last Update Posted: 2014-01-20
• Primary Completion: 2014-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• children ages 6 months-18 years
• suspected sleep-disordered breathing or will attend the pre-operative ENT clinic for adenoidectomy or adenotonsillectomy

Exclusion Criteria

• craniofacial abnormalities
• neurological disorders
• genetic disorders
• infectious disease
• chronic inflammatory disease
• any underlying chronic medical condition

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Plasma inflammatory-markers	After the blood analyzed	Sleep disordered breathing (SDB) in children is associated with increased markers of inflammation, atherogenesis and oxidative stress.

Trial Locations

Locations (1)

Dana Children's hospital, Tel Aviv Medical Center; 🇮🇱 Tel-Aviv, Israel