A study to assess cartilage growth after platelet rich plasma injection for treatment of knee osteoarthritis

Not Applicable

• Conditions: Health Condition 1: M171- Unilateral primary osteoarthritisof knee

• Registration Number: CTRI/2019/06/019593
• Lead Sponsor: Institute of Medical Sciences BHU Varanasi

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

1. Age 40 years to 80 years

2. Clinically and radiologically diagnosed knee OA (American College of Rheumatology Diagnostic Criteria2) with Kellgren and Lawrence radiographic classification8 grade 2 or presence of 1-2 posterior or lateral osteophytes on a posteroanterior view (Early OA)

3. Not responding to conservative management (medications, physical therapy) for at least 6 months

Exclusion Criteria

1. Inflammatory causes of knee arthritis ( rheumatoid, gout )

2. Presence of loose bodies in knee joint, crystal arthropathies or tense joint effusion

3. History of a previous knee joint injection within 3 months or surgery in the past

4. Co-existence of a neuropathic component of pain ( PainDetect pain score of >12 )9

5. Thrombocytopenia (platelet count < 1 lakh/mm3), anemia (hemoglobin < 10 gm%), severe cardiovascular disease or receiving anticoagulant therapy

6. Systemic diseases-Hematologic/ bone malignancy, infection, immunosuppressive status

7. History of smoking

Study & Design

• Study Type: Interventional
• Study Design: Not specified