Radiological assessment of cartilage regeneration after intra-articular platelet-rich plasma (PRP) injection for early osteoarthritis of the knee: a prospective clinical trial

Institute of Medical Sciences BHU Varanasi0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

研究概览

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•1. Age 40 years to 80 years
•2. Clinically and radiologically diagnosed knee OA (American College of Rheumatology Diagnostic Criteria2) with Kellgren and Lawrence radiographic classification8 grade 2 or presence of 1-2 posterior or lateral osteophytes on a posteroanterior view (Early OA)
•3. Not responding to conservative management (medications, physical therapy) for at least 6 months

•1. Inflammatory causes of knee arthritis ( rheumatoid, gout )
•2. Presence of loose bodies in knee joint, crystal arthropathies or tense joint effusion
•3. History of a previous knee joint injection within 3 months or surgery in the past
•4. Co-existence of a neuropathic component of pain ( PainDetect pain score of >12 )9
•5. Thrombocytopenia (platelet count < 1 lakh/mm3), anemia (hemoglobin < 10 gm%), severe cardiovascular disease or receiving anticoagulant therapy
•6. Systemic diseases-Hematologic/ bone malignancy, infection, immunosuppressive status
•7. History of smoking

发起方

Institute of Medical Sciences BHU Varanasi