Rheumatoid Arthritis Comorbidity: Bone Health in Men and African Americans
- Conditions
- Rheumatoid Arthritis
- Registration Number
- NCT00595894
- Lead Sponsor
- University of Nebraska
- Brief Summary
The objective of the proposed study is to assess bone health and determinants of bone health among select subpopulations of rheumatoid arthritis patients.
- Detailed Description
The overall hypothesis of this study is that osteopenia and/or osteoporosis are common among African Americans and men with rheumatoid arthritis and there are identifiable genetic and environmental factors contributing to the pathogenesis of bone loss in these groups.
The Specific Aims of the study are to:
1. Determine baseline hip and lumbar spine bone density (BMD) values and osteopenia/osteoporosis prevalence among African American men and women with early RA and among male veterans with established RA.
2. Identify environmental factors and candidate alleles, which confer increased risk of reduced baseline BMD loss over time among African American men and women with early RA and among male veterans with established RA.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 1745
- Clinical diagnosis of rheumatoid arthritis per ACR guidelines
- Patients with diagnosis > 2yrs (CLEAR study)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Bone mineral density baseline and at 5 years disease Bone mineral density (BMD) test measures calcium and other minerals in bone. Bones containing more minerals are denser, so they tend to be stronger and less likely to break.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Omaha Veteran's Affairs Medical Center
🇺🇸Omaha, Nebraska, United States