Early-life stress, the endocannabinoid system, and fear memory extinctio
- Conditions
- posttraumatic stress disorder
- Registration Number
- NL-OMON23960
- Lead Sponsor
- Radboudumc
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 48
Inclusion Criteria
For both groups:
„Ï Healthy volunteers between 18 and 45 years of age.
Exclusion Criteria
For both groups:
„Ï Body mass index lower than 18.5 or higher than 30.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method autonomic nervous system measurement (skin conductance, heart rate, and pupil dilation responses) and subjective scores on 5-point scale to rate the expectancy of the appearance of the unconditioned stimuli (USs) to fear-conditioned stimuli one day after extinction (i.e., safety learning).
- Secondary Outcome Measures
Name Time Method euroimaging data (founctional and structural neuro images), chemical data (in saliva, and in blood),self-report questionnaires