Effectiveness of low doses of yeast beta-glucan 1,3/1,6 in adults with moderate stress in fighting respiratory infections, reducing fatigue, boosting the immune system and improving digestive health

Not Applicable

• Conditions: Respiratory infections, fatigue, immune system, and digestive health of adults with moderate stress; Not Applicable

• Registration Number: ISRCTN48336189
• Lead Sponsor: Mead Johnson Nutrition Malaysia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-08-04
• Last Update Posted: 12 February 2024
• Study Completion: 2025-09-30

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

Current inclusion criteria as of 16/01/2024:
1. 18-59 years old
2. In a stressful environment
3. Scoring 14-26 (moderate stress) on the Perceived Stress Scale (PSS-10)
4. Symptoms of common colds in the past 6 months
5. Willing to comply with protocol requirements

Previous inclusion criteria:
1. 18-60 years old
2. In a stressful environment
3. Scoring 14-26 (moderate stress) on the Perceived Stress Scale (PSS-10)
4. Symptoms of common colds in the past 6 months
5. Willing to comply with protocol requirements

Exclusion Criteria

1. Participant on immunosuppressant (i.e., steroids)
2. Use of immune-modifying medications or dietary supplements affecting the immune system (at least 2 weeks of washing period for inclusion)
3. Any autoimmune or health concerns
4. Uncontrolled comorbidities including diabetes, hypertension, cardiovascular disease, chronic kidney disease, chronic liver disease, active malignancy, endocrine disorder and cancer
5. Uncontrolled chronic respiratory illness including allergic rhinitis or asthma, presence of nasal ulcers/polyps
6. Body temperature >38?C at study commencement
7. Pregnant/lactating female
8. On specific dietary requirements (diabetic diet/low salt diet/etc)
9. On prebiotics or probiotics supplementation (at least 2 weeks of washing period for inclusion)
10. On antibiotics washing period within 2 weeks for inclusion
11. Disabilities individuals- long-term physical, mental, intellectual and sensory impairment
12. Individuals without symptoms of common colds for the past 6 months
13. Allergy to yeast, oat, wheat, barley
14. Influenza vaccination for the past 1 year
15. Pneumococcal vaccine for the past 5 years
16. Participate in another research study

Study & Design

• Study Type: Interventional
• Study Design: Not specified