Beneficial effects of trehalose eye-drops on the postoperative course after anti-glaucomatous trabeculectomy surgery

Phase 2

• Conditions: primary or secondary open angle glaucoma; glaucoma, open angle; D005902

• Registration Number: JPRN-jRCTs021180008
• Lead Sponsor: akazawa Mitsuru

Brief Summary

A beneficial effect of trehalose ophthalmic drops could not be confirmed during the observation period in this study. This may be due to the fact that intraoperative mitomycin C had already been applied to all patients in this study, which itself has a strong effect of maintaining filtration vesicles and lowering intraocular pressure, which may have masked any effect of the addition of trehalose on inhibiting fibroblast proliferation. A longer study period is needed in the future.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-03-15
• Study Completion: 2022-03-14
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

patients with primary or secondary open angle glaucoma

Exclusion Criteria

patients with angle closure galaucoma, eyes with previous history of trabeculectomy

Study & Design

• Study Type: Interventional
• Study Design: Not specified