CTRI/2025/08/092626尚未招募4 期
Comparative efficacy of topical tofacitinib versus topical calcipotriol as an adjuvant therapy in chronic plaque psoriasis.
Government Medical College and Hospital1 个研究点 分布在 1 个国家目标入组 40 人开始时间: 2025年10月1日最近更新:
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Percentage reduction in Psoriasis Area and Severity Index (PASI) score
研究概览
简要总结
40 patients with chronic plaque psoriasis that
fulfil the inclusion criteria shall be recruited
and randomised with the help of random table
method into two groups:
Mid-potency topical corticosteroid cream
(betamethasone dipropionate) shall be used in
all patients for once daily application, applied
in the morning.
Group A will receive topical tofacitinib 2%
ointment once daily application, applied at
night. Group B will receive topical calcipotriol
0.005% ointment once daily application,
applied at night.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- None
入排标准
- 年龄范围
- 15.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients with chronic plaque psoriasis not requiring systemic medication.
排除标准
- •Non-plaque forms of psoriasis History or evidence of psoriatic arthritis Use of any systemic agent or phototherapy in the last 2 weeks Any co-existing serious systemic illness requiring long-term medication Any infection requiring hospitalization within the past 2 weeks Pregnancy/lactation.
结局指标
主要结局
Percentage reduction in Psoriasis Area and Severity Index (PASI) score
时间窗: at 12 weeks
次要结局
- Proportion of patients achieving PASI 50 & PASI 75 responses(At baseline & 12 weeks)
- Change in Physician’s Global Assessment (PGA) score(Baseline and 12 weeks)
- Change in patient satisfaction scores(Baseline and 12 weeks)
- Incidence of adverse effects and overall tolerability(Baseline to 12 weeks)
研究者
Dr Aarshia Bajaj
Government Medical College and Hospital, Sector 32, Chandigarh
研究点 (1)
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