The Corona and COVID-19 Study in Telemark and Agder - COVITA
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 1,200
- 试验地点
- 1
- 主要终点
- Risk factors for COVID-19
研究概览
简要总结
Through SARS-CoV-2 IgG testing of PCR positive and negative cases the study will follow the COVID-19 immune response by monitoring the SARS-CoV-2 IgG antibody levels over a period of two years. Further, risk factors will be identified by the use of the test-negative design including population controls, allowing comparison of participants with positive and negative tests, and with population controls (triangulation). Special emphasis will be on high risk groups in general and on different occupational, environmental and socio-economic groups in particular. Finally, severity of illness, deaths and the use of health care during will be assessed using national register data from Telemark and Agder.
详细描述
Objectives
The main objectives are:
- Monitor the incidence of COVID-19 and the development of the SARS-CoV-2-IgG levels of cases in Agder and Telemark over a period of two years (WP1).
- Identify risk factors for COVID-19 by comparison of SARS-CoV-2 antibody positive and negative cases in Telemark and Agder, and comparison of these groups separately with population controls (WP2).
- The incidence of neurocognitive symptoms and fatigue in COVID-19 patients (WP3).
- Investigation of severity, death and the use of health care for the COVID-19 patients based on data from national registers (WP4).
The main exposures are (WP1-3):
- Infection (mild, severe) with COVID-19.
- Occupational risk factors assessed by occupational codes (ISCO88) and job exposure matrix categorisation.
- Environmental risk factors (road traffic outside bedroom window, travel by foot or bicycle alongside busy roads, and the use of a fireplaces in residential homes. Further, estimated measurements of air pollution may be linked to participants' home address.
- Socioeconomic status; age, sex, comorbidity, medication use, lifestyle factors (smoking, BMI, physical activity, others), geographic region/municipality, education and income.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18 - 85 years
- •Performed SARS-CoV-2 PCR test
排除标准
- •Non-Norwegian speakers.
- •inability to answer questionnaire due to dementia or similar conditions
结局指标
主要结局
Risk factors for COVID-19
时间窗: 2020-2026
Different risk factors (age, sex, education, comorbidity, occupational and environmental exposure will be assessed
SARS-CoV-2 IgG antibody level
时间窗: 2020-2023
Serum Levels of SARS-CoV-2 IgG antibody and the Development of these over a two years period
次要结局
未报告次要终点
研究者
Anne Kristin M. Fell
Associate Professor, senior physician
Sykehuset Telemark