A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Severe Eosinophilic Asthma (EXHALE-3)
- Conditions
- Asthma; EosinophilicEosinophilic AsthmaAsthma
- Interventions
- Drug: Placebo
- Registration Number
- NCT05813288
- Lead Sponsor
- Areteia Therapeutics
- Brief Summary
The objective of this clinical study is to investigate the safety, tolerability, and efficacy of dexpramipexole in participants with inadequately controlled severe eosinophilic asthma.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 930
-
Signed informed consent form and assent form, as appropriate.
-
Male or female ≥12 years of age at Screening Visit 1.
Asthma-related criteria
-
Documented physician diagnosis of asthma for ≥12 months prior to Screening Visit 1.
-
Eosinophil count of ≥0.30x10⁹/L at Screening Visit 1. If the initial value is between 0.250x10⁹/L to 0.299x10⁹/L, then this may be repeated once at an unscheduled visit (prior to Screening Visit 2).
-
Treatment of asthma, participants must satisfy all the below (items a to c):
- Participants who have received asthma controller medication with medium or high dose inhaled corticosteroids (ICS ≥500 μg/day fluticasone propionate dry powder formulation daily or clinically comparable, per GINA 2021) on a regular basis for at least 12 months prior to Screening Visit 1.
- Documented treatment with a stable dose of either medium or high dose ICS for at least 3 months prior to Visit 1. The ICS may be contained within an ICS/long-acting β2 agonist (LABA) combination product. Daily oral corticosteroids are an allowed concomitant medication; participants on daily oral corticosteroids must be on a stable dose for 3 months before Screening Visit 1.
- Use of one of more additional daily maintenance asthma controller medications according to standard practice of care is required. Use of a stable dose of any additional asthma controller medications must be documented for at least 3 months prior to Screening Visit 1.
-
Pre-BD FEV₁ ≥40% and <80% (<90% for participants 12 to 17 years of age) of predicted at Screening Visit 2.
-
Variable airflow obstruction documented with at least one of the following criteria:
- Bronchodilator reversibility at Screening Visit 2, as evidenced by ≥12% and ≥200 mL improvement in FEV₁, 15 to 30 minutes following inhalation of 400 µg (four puffs) of albuterol/salbutamol (≥12% and ≥160 mL for ages 12 to 17). Participants who do not meet the bronchodilator reversibility inclusion criterion but have ≥10% and ≥160 mL reversibility, may repeat the reversibility spirometry assessment once during the Screening period, at an unscheduled visit at least 7 days prior to baseline.
- Bronchodilator reversibility, using the criteria above, documented in the past 24 months prior to Screening Visit 1 or during Screening.
- Peak flow variation of ≥20% over a 2-week period, documented in the past 24 months prior to Screening Visit 1 or during Screening.
- Airflow variability in clinic FEV₁ ≥20% between two consecutive clinic visits, documented in the past 24 months prior to Screening Visit 1.
- Airway hyperresponsiveness (provocative concentration causing a 20% fall in FEV₁ of methacholine <8 mg/mL or other clinically relevant bronchoprovocation testing) documented in the past 24 months prior to Screening Visit 1 or during Screening.
-
ACQ-6 ≥1.5 at Screening Visit 2.
-
Documented history of at least two asthma exacerbations requiring treatment with systemic corticosteroids (intramuscular, intravenous, or oral) within the past 12-month period prior to Screening Visit 1.
General medical history
-
Negative urine pregnancy test for women of childbearing potential (WOCBP; after menarche) at the Screening and Baseline visits.
-
WOCBP must use either of the following methods of birth control, from Screening Visit 1 through the End of Study Visit:
-
A highly effective form of birth control (confirmed by the investigator). Highly effective forms of birth control include: true sexual abstinence, a vasectomized sexual partner, Implanon, female sterilization by tubal occlusion, any effective Intrauterine device (IUD), IUD/intrauterine system (IUS), Levonorgestrel Intrauterine system, or oral contraceptive.
- Or
-
Two protocol acceptable methods of contraception in tandem.
Women not of childbearing potential are defined as women who are either permanently sterilized (hysterectomy, bilateral oophorectomy, or bilateral salpingectomy), or who are postmenopausal. Women will be considered postmenopausal if they have been amenorrheic for ≥12 months prior to the planned date of the Baseline Visit without an alternative medical cause. The following age specific requirements apply:
-
Women <50 years old will be considered postmenopausal if they have been amenorrheic for 12 months or more following cessation of exogenous hormonal treatment and follicle stimulating hormone levels in the postmenopausal range.
-
Women ≥50 years old will be considered postmenopausal if they have been amenorrheic for 12 months or more following cessation of all exogenous hormonal treatment.
-
Asthma-related criteria
-
A participant who experiences a severe asthma exacerbation (defined as a deterioration of asthma that results in emergency treatment, hospitalization due to asthma, or treatment with systemic corticosteroids) at any time from 4 weeks prior to Screening Visit 1.
Participants who experience an asthma exacerbation during the Screening/Run-in Period may remain in screening and proceed with study visits 14 days after they have completed their course of oral steroids or returned to their pre-Screening Visit maintenance dose of oral steroids and the investigator considers participant has returned to baseline status.
-
Current diagnosis of diseases which may confound interpretation of this study's findings such as allergic bronchopulmonary aspergillosis, eosinophilic granulomatosis with polyangiitis, eosinophilic gastrointestinal diseases, hypereosinophilic syndrome, or lung diseases (eg, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis).
-
Respiratory infection: Upper or lower respiratory tract, sinus, or middle ear infection within the 4 weeks before Screening Visit 1.
Prohibited medications/procedures
-
Treatment with a biologic investigational drug in the last 5 months prior to Screening Visit 1. Treatment with non-biologic investigational drugs in the previous 30 days or five-half-lives prior to Screening Visit 1, whichever is longer. Treatment with GSK3511294 (long-acting anti-IL-5) in the past 12 months.
-
Treatment with any of the following monoclonal antibody therapies within 120 days prior to Baseline: benralizumab, dupilumab, mepolizumab, reslizumab, omalizumab, tezepelumab, or tralokinumab.
-
Treatment with pramipexole (Mirapex®) within 30 days of Baseline.
-
Treatment with selected drugs known to have a substantial risk of neutropenia in the past 30 days prior to Screening Visit 1.
-
Bronchial thermoplasty procedure in the past 12 months prior to Screening Visit 1 or planned during the coming year.
General medical history
-
Weight <40 kg at Screening Visit 1.
-
Current smoking within 12 months prior to Screening Visit 1 or a smoking history of >10 pack-years. Smoking includes tobacco, vaping, and/or marijuana use.
-
Known or suspected alcohol or drug abuse
-
Uncontrolled severe hypertension: systolic blood pressure >180 mmHg or diastolic blood pressure >110 mmHg prior to Baseline Visit despite anti-hypertensive therapy.
-
History of malignancy that required surgery (excluding local and wide-local excision), radiation therapy and/or systemic therapy during the 5 years prior to Baseline Visit.
-
History of human immunodeficiency virus (HIV) infection or chronic infection with hepatitis B or C.
-
A helminth parasitic infection diagnosed within 24 weeks prior Screening Visit 1 that has not been treated with or has failed to respond to standard of care (SoC) therapy.
-
Medical or other condition likely to interfere with participant's ability to undergo study procedures, adhere to visit schedule, or comply with study requirements.
-
Known or suspected noncompliance with medication.
-
Unwillingness or inability to follow the procedures outlined in the protocol.
Clinical safety labs
-
Absolute neutrophil count <2.000x10⁹/L at screening at Screening Visit 1 or Screening Visit 2.
-
Renal dysfunction, defined as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m² at Screening Visit 2 (using the Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] formula [Levey et al, 2009] for age ≥18 years at screening; using the Bedside Schwartz [Schwartz and Work, 2009] eGFR formula for age <18).
-
Active liver disease defined as any known current infectious, neoplastic, or metabolic pathology of the liver or unexplained elevations in alanine aminotransferase (ALT), aspartate aminotransferase (AST), >3x the upper limit of normal (ULN), or total bilirubin >2x ULN at Screening Visit 2 confirmed by a repeat abnormal measurement of the relevant value(s), at least 1 week apart.
Cardiac safety
-
History of New York Heart Association class IV heart failure or last known left ventricular ejection fraction <25%.
-
History of major adverse cardiovascular event (MACE) within 3 months prior to the Baseline Visit.
-
History of cardiac arrhythmia within 3 months prior to Baseline Visit that is not controlled by medication or via ablation.
-
History of long QT syndrome.
-
Corrected QT interval by Fridericia (QTcF) interval >450 ms for males and >470 ms for females at Screening Visit 2 or QTcF ≥480 ms for participants with bundle branch block.
-
Clinically important abnormalities in resting ECG that may interfere with the interpretation of QTcF interval changes at Screening Visit 2, including heart rate <45 beats per minute (bpm) or >100 bpm.
Pregnancy/Lactation
-
Pregnant women or women breastfeeding.
-
Males who are unwilling to use an acceptable method of birth control during the entire study period (ie, condom with spermicide).
-
Allergy or hypersensitivity to dexpramipexole or any of its components.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 150 mg BID Dexpramipexole Dihydrochloride Dexpramipexole 150 mg oral tablet taken twice a day Placebo Placebo Placebo oral tablet taken twice a day 75 mg BID Dexpramipexole Dihydrochloride Dexpramipexole 75 mg oral tablet taken twice a day
- Primary Outcome Measures
Name Time Method Annualized rate of severe asthma exacerbations over 52 weeks. Day 1 (baseline, pre-dose) through Week 52 A severe exacerbation was defined as a deterioration of asthma requiring: use of systemic corticosteroids for \>=3 days; or hospitalization or emergency room visit because of asthma, requiring systemic corticosteroids; or death due to asthma.
- Secondary Outcome Measures
Name Time Method Absolute Change in pre-bronchodilator forced expiratory volume (Pre-BD FEV₁) from Baseline Day 1 (baseline, pre-dose), Weeks 36, 44, 52 The absolute change from baseline in pre-bronchodilator forced expiratory volume, averaged across visits at Weeks 36, 44, and 52.
Mean Change From Baseline at Week 52 in Asthma Control Questionnaire-6 (ACQ-6) (Key Secondary Endpoint) From randomization to Study Week 52 Change from baseline in ACQ-6 as compared to placebo at Week 52. The ACQ-6 captures asthma symptoms and short-acting β2-agonist use via subject-report. Questions are weighted equally and scored from 0 (totally controlled) to 6 (severely uncontrolled). The ACQ-6 score is the mean of the responses
Mean Change From Baseline at Week 52 in Standardized Asthma Quality of Life Questionnaire for 12 Years and Older (AQLQ+12) Total Score (Key Secondary Endpoint) From randomization to Study Week 52 Mean change from baseline in AQLQ+12 as compared to placebo at Week 52. The AQLQ+12 is a questionnaire that measures the health-related quality of life experienced by asthma subjects. The total score is defined as the average of all 32 questions in the AQLQ+12 questionnaire. AQLQ+12 is a 7-point scale questionnaire, ranging from 7 (no impairment) to 1 (severe impairment).
Annualized rate of severe exacerbations requiring an emergency over 52 weeks department visit or hospitalization Day 1 (baseline, pre-dose), Week 52 Annualized rate of severe exacerbations (AAER) from Week 4 to Week 52. Week 4 through Week 52 Change in absolute eosinophil count (AEC) Day 1 (baseline, pre-dose), Weeks 35, 44, and 52 Average change from baseline in forced vital capacity (FVC) Day 1(baseline, pre-dose), Weeks 36, 44, and 52 FVC, change from baseline at Weeks 4, 12, 20, 28, 36, 44, and 52. Day 1(baseline, pre-dose), Weeks 4, 12, 20, 28, 36, 44, and 52. Post-bronchodilator FEV₁, change from baseline to Week 52 Day 1 (baseline, pre-dose) through Week 52 Time to first severe asthma exacerbation Up to Week 52 Mean Change From Baseline at Week 52 in Asthma Symptom Diary (ASD) From randomization to Study Week 52 The Asthma Symptom Diary comprises of 10 items (5 items in the morning; 5 items in the evening). Asthma symptoms during night time and daytime are recorded by the patient each morning and evening in the daily diary. A daily ASD score is the mean of the 10 items. Responses for all 10 items are required to calculate the daily ASD score; otherwise, it is treated as missing. For the 7-day average asthma symptom score, scoring is done with no imputation using the mean of at least 4 of the 7 daily ASD scores as a mean weekly item score. The 7-day average ASD score ranges from 0 to 4, where 0 indicates no asthma symptoms.
Mean Change From Baseline at Week 52 in EQ-5D-5L At Study Week 52 EQ-5D-5L allows subjects to rate current health status on a scale of 0-100, with 0 being the worst imaginable health state.
Trial Locations
- Locations (249)
Research Site 30049-004
🇩🇪Cottbus, Germany
Research Site 30049-082
🇩🇪Delitzsch, Germany
Research Site 30049-059
🇩🇪Frankfurt, Germany
Research Site 30049-019
🇩🇪Frankfurt, Germany
Research Site 30049-006
🇩🇪Furstenwalde, Germany
Research Site 30049-035
🇩🇪Hannover, Germany
Research Site 30049-073
🇩🇪Homburg, Germany
Research Site 30049-061
🇩🇪Leipzig, Germany
Research Site 30049-056
🇩🇪Leipzig, Germany
Research Site 30049-051
🇩🇪Munich, Germany
Research Site 30049-028
🇩🇪Munich, Germany
Research Site 30036-005
🇭🇺Balassagyarmat, Hungary
Research Site 30036-001
🇭🇺Budapest, Hungary
Research Site 30036-014
🇭🇺Debrecen, Hungary
Research Site 30036-017
🇭🇺Edelény, Hungary
Research Site 30036-013
🇭🇺Godollo, Hungary
Research Site 30036-006
🇭🇺Szeged, Hungary
Research Site US-30001-414
🇺🇸Franklin, Tennessee, United States
Research Site 30054-048
🇦🇷Buenos Aires, Argentina
Research Site 30001-287
🇺🇸Mobile, Alabama, United States
Research Site 30001-487
🇺🇸Chandler, Arizona, United States
Research Site 30001-462
🇺🇸Peoria, Arizona, United States
Research Site US-30001-462
🇺🇸Peoria, Arizona, United States
Research Site 30001-322
🇺🇸Surprise, Arizona, United States
Research Site 30001-010
🇺🇸Little Rock, Arkansas, United States
Research Site 30001-485
🇺🇸Inglewood, California, United States
Research Site 30001-497
🇺🇸Los Angeles, California, United States
Research Site 30001-489
🇺🇸Pasadena, California, United States
Research Site US-30001-434
🇺🇸San diego, California, United States
Research Site 30001-484
🇺🇸Santa Monica, California, United States
Research Site US-30001-304
🇺🇸Valencia, California, United States
Research Site 30001-305
🇺🇸Valencia, California, United States
Research Site 30001-291
🇺🇸Jacksonville, Florida, United States
Research Site 30001-318
🇺🇸Maitland, Florida, United States
Research Site 30001-311
🇺🇸Miami, Florida, United States
Research Site 30001-288
🇺🇸Miami, Florida, United States
Research Site 30001-310
🇺🇸Miami, Florida, United States
Research Site 30001-329
🇺🇸Miami, Florida, United States
Research Site 30001-082
🇺🇸Miami, Florida, United States
Research Site 30001-301
🇺🇸Naples, Florida, United States
Research Site 30001-348
🇺🇸Ocala, Florida, United States
Research Site 30001-331
🇺🇸Orlando, Florida, United States
Research Site 30001-293
🇺🇸Orlando, Florida, United States
Research Site 30001-312
🇺🇸Pembroke Pines, Florida, United States
Research Site US-30001-429
🇺🇸Plantation, Florida, United States
Research Site 30001-319
🇺🇸Viera, Florida, United States
Research Site US-30001-452
🇺🇸Dunwoody, Georgia, United States
Research Site 30001-483
🇺🇸East Point, Georgia, United States
Research Site 30001-366
🇺🇸Lilburn, Georgia, United States
Research Site 30001-328
🇺🇸Maywood, Illinois, United States
Research Site 30001-347
🇺🇸Louisville, Kentucky, United States
Research Site US-30001-437
🇺🇸Alexandria, Louisiana, United States
Research Site 30001-286
🇺🇸Lafayette, Louisiana, United States
Research Site 30001-313
🇺🇸Marrero, Louisiana, United States
Research Site US-30001-352
🇺🇸Zachary, Louisiana, United States
Research Site 30001-472
🇺🇸Farmington Hills, Michigan, United States
Research Site 30001-442
🇺🇸Southfield, Michigan, United States
Research Site 30001-372
🇺🇸Warren, Michigan, United States
Research Site 30001-421
🇺🇸Mankato, Minnesota, United States
Research Site 30001-363
🇺🇸Edison, New Jersey, United States
Research Site 30001-474
🇺🇸Massena, New York, United States
Research Site 30001-455
🇺🇸New York, New York, United States
Research Site US-30001-369
🇺🇸New York, New York, United States
Research Site 30001-300
🇺🇸Schenectady, New York, United States
Research Site US-30001-398
🇺🇸Charlotte, North Carolina, United States
Research Site 30001-439
🇺🇸Rocky Mount, North Carolina, United States
Research Site 30001-413
🇺🇸Cleveland, Ohio, United States
Research Site 30001-495
🇺🇸Columbus, Ohio, United States
Research Site US-30001-327
🇺🇸Philadelphia, Pennsylvania, United States
Research Site US-30001-364
🇺🇸Memphis, Tennessee, United States
Research Site 30001-334
🇺🇸Allen, Texas, United States
Research Site 30001-090
🇺🇸Austin, Texas, United States
Research Site 30001-290
🇺🇸Austin, Texas, United States
Research Site 30001-415
🇺🇸Dallas, Texas, United States
Research Site US-30001-418
🇺🇸Frisco, Texas, United States
Research Site 30001-299
🇺🇸Houston, Texas, United States
Research Site 30001-315
🇺🇸Katy, Texas, United States
Research Site 30001-295
🇺🇸McKinney, Texas, United States
Research Site 30001-373
🇺🇸Mesquite, Texas, United States
Research Site 30001-481
🇺🇸Nederland, Texas, United States
Research Site 30001-297
🇺🇸Pearland, Texas, United States
Research Site 30001-238
🇺🇸San Antonio, Texas, United States
Research Site 30001-377
🇺🇸San Antonio, Texas, United States
Research Site 30001-335
🇺🇸Sugar Land, Texas, United States
Research Site 30001-333
🇺🇸Pleasant View, Utah, United States
Research Site 30054-035
🇦🇷Buenos Aires, Argentina
Research Site 30054-031
🇦🇷Buenos Aires, Argentina
Research Site 30054-045
🇦🇷Buenos Aires, Argentina
Research Site 30054-026
🇦🇷Buenos Aires, Argentina
Research Site 30054-049
🇦🇷Buenos Aires, Argentina
Research Site 30054-050
🇦🇷Buenos Aires, Argentina
Research Site 30054-044
🇦🇷Buenos Aires, Argentina
Research Site -30054-012
🇦🇷Buenos Aires, Argentina
Research Site 30054-034
🇦🇷Buenos Aires, Argentina
Research Site 30054-024
🇦🇷Buenos Aires, Argentina
Research Site 30054-008
🇦🇷Buenos Aires, Argentina
Research Site -30054-043
🇦🇷Buenos Aires, Argentina
Research Site 30054-054
🇦🇷Concepcion del Uruguay, Argentina
Research Site 30054-051
🇦🇷Cordoba, Argentina
Research Site 30054-052
🇦🇷Cordoba, Argentina
Research Site 30054-047
🇦🇷Mendoza, Argentina
Research Site 30054-010
🇦🇷Mendoza, Argentina
Research Site 30054-032
🇦🇷Mendoza, Argentina
Research Site 30054-028
🇦🇷Mendoza, Argentina
Research Site 30054-042
🇦🇷Santa Fe, Argentina
Research Site 30055-036
🇧🇷Curitiba, Brazil
Research Site 30055-021
🇧🇷Porto Alegre, Brazil
Research Site 30055-035
🇧🇷Rio de Janeiro, Brazil
Research Site 30055-025
🇧🇷Sao Paulo, Brazil
Research Site 30056-013
🇨🇱Santiago, Chile
Research Site 30056-009
🇨🇱Curico, Chile
Research Site 30056-007
🇨🇱Santiago, Chile
Research Site 30056-011
🇨🇱Santiago, Chile
Research Site 30056-010
🇨🇱Santiago, Chile
Research Site 30056-006
🇨🇱Santiago, Chile
Research Site 30056-012
🇨🇱Santiago, Chile
Research Site 30056-005
🇨🇱Temuco, Chile
Research Site 30056-014
🇨🇱Vina Del Mar, Chile
Research Site 20086-021
🇨🇳Shanghai, China
Research Site 30385-008
🇭🇷Zadar, Croatia
Research Site 30385-002
🇭🇷Zagreb, Croatia
Research Site 30385-007
🇭🇷Zagreb, Croatia
Research Site 30420-018
🇨🇿Brno, Czechia
Research Site 30420-012
🇨🇿Brno, Czechia
Research Site 30420-003
🇨🇿Jindrichuv Hradec, Czechia
Research Site 30420-007
🇨🇿Lovosice, Czechia
Research Site 30420-014
🇨🇿Olomouc, Czechia
Research Site 30420-010
🇨🇿Strakonice, Czechia
Research Site 30420-009
🇨🇿Teplice, Czechia
Research Site 30033-012
🇫🇷Cholet, France
Research Site 30033-005
🇫🇷Grenoble Cedex 9, France
Research Site 30033-013
🇫🇷Libourne, France
Research Site 30033-014
🇫🇷Lille Cedex, France
Research Site 30033-002
🇫🇷Lyon Cedex 4, France
Research Site 30033-001
🇫🇷Marseille, France
Research Site 30033-006
🇫🇷Marseille, France
Research Site 30033-007
🇫🇷Montpellier Cedex 5, France
Research Site 30033-003
🇫🇷Paris, France
Research Site 30033-015
🇫🇷Reims, France
Research Site 30033-004
🇫🇷Saint Herblain, France
Research Site 30049-081
🇩🇪Augsburg, Germany
Research Site 30049-060
🇩🇪Berlin, Germany
Research Site 30049-005
🇩🇪Berlin, Germany
Research Site 30036-018
🇭🇺Szigetvar, Hungary
Research Site 30091-006
🇮🇳Ahmedabad, Gujarat, India
Research Site 30091-010
🇮🇳Ahmedabad, Gujarat, India
Research Site 30091-011
🇮🇳Himmatnagar, Gujarat, India
Research Site 30091-001
🇮🇳Sūrat, Gujarat, India
Research Site 30091-024
🇮🇳Rohtak, Haryana, India
Research Site 30091-043
🇮🇳Aurangabad, Maharashta, India
Research Site 30091-004
🇮🇳Nagpur, Maharashta, India
Research Site 30091-023
🇮🇳Nagpur, Maharashta, India
Research Site 30091-033
🇮🇳Pune, Maharashta, India
Research Site 30091-018
🇮🇳Jaipur, Rajasthan, India
Research Site 30091-021
🇮🇳Kanpur, India
Research Site 30972-008
🇮🇱Beer-Sheva, Israel
Research Site 30972-001
🇮🇱Jerusalem, Israel
Research Site 30972-009
🇮🇱Kfar Saba, Israel
Research Site 30972-011
🇮🇱Ramat Gan, Israel
Research Site 30972-005
🇮🇱Sha'ar Ha'Aliya, Israel
Research Site 30039-004
🇮🇹Bergamo, Italy
Research Site 30039-013
🇮🇹Napoli, Italy
Research Site 30039-002
🇮🇹Padova, Italy
Research Site 30039-017
🇮🇹Reggio Emilia, Italy
Research Site 30039-011
🇮🇹Roma, Italy
Research Site 20081-010
🇯🇵Kanazawa, Japan
Research Site 30082-019
🇰🇷Gwangju, Korea, Republic of
Research Site 30082-022
🇰🇷Seoul, Korea, Republic of
Research Site 30082-018
🇰🇷Seoul, Korea, Republic of
Research Site 20082-028
🇰🇷Seoul, Korea, Republic of
Research Site 30082-010
🇰🇷Suwon, Korea, Republic of
Research Site 30082-017
🇰🇷Wŏnju, Korea, Republic of
Research Site 30370-016
🇱🇹Kaunas, Lithuania
Research Site 30370-017
🇱🇹Klaipeda, Lithuania
Research Site 30370-002
🇱🇹Vilnius, Lithuania
Research Site 30052-024
🇲🇽Guadalajara, Jalisco, Mexico
Research Site 30052-025
🇲🇽Morelia, Michoacon, Mexico
Research Site 30052-026
🇲🇽Chihuahua, Mexico
Research Site 30052-030
🇲🇽Durango, Mexico
Research Site 30052-033
🇲🇽Leon, Mexico
Research Site 30052-028
🇲🇽Mexico City, Mexico
Research Site 30052-023
🇲🇽Monterrey, Mexico
Research Site -30051-023
🇵🇪Arequipa, Peru
Research Site 30051-022
🇵🇪Lima, Peru
Research Site 30051-026
🇵🇪Lima, Peru
Research Site 30051-020
🇵🇪Lima, Peru
Research Site -30051-028
🇵🇪Lima, Peru
Research Site 30051-017
🇵🇪Lima, Peru
Research Site 30051-021
🇵🇪Lima, Peru
Research Site 30787-388
🇵🇷Rio Piedras, Puerto Rico
Research Site 30001-383
🇵🇷San Juan, Puerto Rico
Research Site 30787-405
🇵🇷San Juan, Puerto Rico
Research Site 30001-345
🇵🇷Vega Baja, Puerto Rico
Research Site 30027-013
🇿🇦Benoni, South Africa
Research Site 30027-009
🇿🇦Cape Town, South Africa
Research Site 30027-011
🇿🇦Cape Town, South Africa
Research Site 30027-012
🇿🇦Cape Town, South Africa
Research Site 30027-021
🇿🇦Cape Town, South Africa
Research Site 30027-007
🇿🇦Durban, South Africa
Research Site 30027-001
🇿🇦Durban, South Africa
Research Site 30027-014
🇿🇦Durban, South Africa
Research Site 30027-023
🇿🇦Durban, South Africa
Research Site 30027-010
🇿🇦Durban, South Africa
Research Site 30027-030
🇿🇦Johannesburg, South Africa
Research Site 30027-026
🇿🇦Johannesburg, South Africa
Research Site 30027-031
🇿🇦Krugersdorp, South Africa
Research Site 30027-008
🇿🇦KwaZulu, South Africa
Research Site 30027-032
🇿🇦Plettenberg Bay, South Africa
Research Site 30027-029
🇿🇦Polokwane, South Africa
Research Site 30027-004
🇿🇦Pretoria, South Africa
Research Site 30027-019
🇿🇦Pretoria, South Africa
Research Site 30027-015
🇿🇦Thabazimbi, South Africa
Research Site 30027-018
🇿🇦Vereeniging, South Africa
Research Site 30027-017
🇿🇦Welkom, South Africa
Research Site 30034-046
🇪🇸A Coruna, Spain
Research Site 30034-052
🇪🇸A Coruna, Spain
Research Site 30034-011
🇪🇸Barcelona, Spain
Research Site 30034-049
🇪🇸Barcelona, Spain
Research Site 30034-013
🇪🇸Barcelona, Spain
Research Site 30034-021
🇪🇸Lugo, Spain
Research Site 30034-053
🇪🇸Madrid, Spain
Research Site 30034-037
🇪🇸Madrid, Spain
Research Site 30034-045
🇪🇸Madrid, Spain
Research Site 30034-050
🇪🇸Santander, Spain
Research Site 30034-043
🇪🇸Valencia, Spain
Research Site 30034-041
🇪🇸Vigo, Spain
Research Site 30886-013
🇨🇳Douliu, Taiwan
Research Site 30886-004
🇨🇳New Taipei City, Taiwan
Research Site 30886-006
🇨🇳New Taipei City, Taiwan
Research Site 30886-005
🇨🇳Taichung, Taiwan
Research Site 30886-007
🇨🇳Taichung, Taiwan
Research Site 30886-011
🇨🇳Tainan, Taiwan
Research Site 30886-010
🇨🇳Taipei, Taiwan
Research Site 30886-008
🇨🇳Taipei, Taiwan
Research Site 30886-003
🇨🇳Taipei, Taiwan
Research Site 30886-009
🇨🇳Taipei, Taiwan
Research Site 30090-018
🇹🇷Ankara, Turkey
Research Site 30090-021
🇹🇷Ankara, Turkey
Research Site 30090-008
🇹🇷Ankara, Turkey
Research Site 30090-009
🇹🇷Ankara, Turkey
Research Site 30090-019
🇹🇷Bornova, Turkey
Research Site 30090-020
🇹🇷Istanbul, Turkey
Research Site 30090-013
🇹🇷Mersin, Turkey
Research Site 30380-002
🇺🇦Chernivtsi, Ukraine
Research Site 30380-011
🇺🇦Kyiv, Ukraine
Research Site 30044-027
🇬🇧Glasgow, United Kingdom
Research Site 30044-059
🇬🇧High Wycombe, United Kingdom
Research Site 30044-039
🇬🇧Leicester, United Kingdom
Research Site 30044-025
🇬🇧Sheffield, United Kingdom