NL-OMON55835已完成不适用
Dose individualization of Antibiotics in ICU patients: to TDM or not to TDM and the effects on outcome (DOLPHIN-trial) - DOLPHI
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 486
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •All patients admitted to the adult general ICU wards and given standard of care
- •intravenous therapy of the target antibiotic are screened for participating in
- •Patients will be admitted to the cohorts based upon the following three cohorts:
- •1. Main cohort (COVID-19 Negative, No continuous infusion)
- •2. COVID-19 cohort (including continuous infusion)
- •3. Continuous infusion cohort (COVID-19 Negative)
- •Antibiotic initiation based on clinical suspicion of infection and/or cultured
- •pathogens susceptible to the target drugs, initial dosage prescription, and
- •duration of therapy are at the discretion of the attending physician. , In
- •order to be eligible to participate in this study, a subject must also meet all
- •of the following criteria:
- •* *18 years of age
- •* Receiving intravenous antibiotic therapy of the target drugs (including
- •continuous infusion)
- •* Treatment should be aimed for at least 2 days.
- •* Written informed consent has been obtained from the patient or their legally
- •authorized representative.
排除标准
- •A potential subject who meets any of the following criteria will be excluded
- •from participation in this study:
- •* Pregnancy
- •* Patient already enrolled in this trial
- •* Antibiotic cessation before sampling
- •* Medium care and burn wound patients admitted to the ICU
- •* Patients receiving target antibiotics only as prophylaxis within the context
- •of Selective Digestive tract Decontamination (SDD)
研究者
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