Conjuran®(Polynucleotide) for knee Osteoarthritis

Not Applicable

Active, not recruiting

• Conditions: Diseases of the musculo-skeletal system and connective tissue

• Registration Number: KCT0005555
• Lead Sponsor: The Catholic University of Korea, Seoul St. Mary's Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 3 November 2020

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

1) adult over 40 years old
2) Knee osteoarthritis patients of Grade l-lll according to Kellgren-Lawrence grading scale
3) 100mm VAS(visual analogue score) for pain during weight bearing more than 40mm in at least one joint of the bilateral knee joint

Exclusion Criteria

1) patient with severe trauma or fracture history of the indicator knee joint
2) Those with rheumatoid arthritis or other metabolid arthritis
3) Patient with infection around the indicator knee joint
4) Those who have joint replacement surgery in the indicator knee joint
5) Those who have hip joint osteoarthritis in ipsilateral side of the indicator knee joint
6) Patient with other disease that may affect the safety and effectiveness evaluation of the indicator knee joint (e.g., patients with severe pain, such as complex pain regional syndrome, Paget's disease, intervertebral disc prolapse, and gout, recurrent pseudogout)
7) patient who received intra-articular hyaluronic acid injection within the previous three months of baseline(before study) or those who received intra-articular steroid injections within one month
8) those who received anticoagulant or platelet aggregation inhibitors within one week prior to the baseline (before study)
9) patient who received physiotherapy in the baseline (before study) within two weeks prior to the indicator knee joint

Study & Design

• Study Type: Observational Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Visual analogue score (VAS);Korean version of Western Ontario and McMaster Universities(K-WOMAC);European quality of like-5 demension(EQ-5D);PainDETECT

Secondary Outcome Measures

Name	Time	Method
Safety assessment