Efficacy of amantadine on behavioural and emotional problems and impairment of executive functioning due to acquired brain injury to the frontal lobes: a series of single case experimental design studies.

GGZ Oost Brabant0 个研究点目标入组 40 人开始时间: 2014年10月1日最近更新: 2019年2月28日

适应症

试验速览

暂无简介。

•Subjects have suffered acquired brain damage due to various aetiologies as verified by CT or MRI • Subjects suffer from emotional lability/irritability, aggressiveness, apathy as established through clinical observation and/or impairment of executive functioning as established by clinical judgement or on the basis of neuropsychological assesment. • Subjects are >3 months post injury • Subjects are 18 years or older • Written informed consent is given
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 40
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•Current drug addiction
•Current psychoses • The current use of incompatible medications: methylphenidate, typical or atypical antipsychotics, combination diuretics (hydrochlorthiazide + potassium sparing diuretics) or Levodopa. • Pregnancy and lactation • Cardiac disease. Inclusion only after the consulting cardiologists consent • Refractory epilepsy • Kidney failure (eGFR<10 ml/min) • A history of gastric ulceration • Current glaucoma • Hypersensitivity to amantadine or any of the excipients

发起方

GGZ Oost Brabant