NCT01739283已完成不适用
GIP and GLP-1 in Type 1 Diabetes
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- plasma glucagon area under curve values
研究概览
简要总结
Investigation of Glucose-dependent Insulinotropic Polypeptide (GIP) effects at hyper and hypoglycemia in type 1 diabetes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with type 1 diabetes (WHO criteria)
排除标准
- •HbA1c > 9 %
- •Liver disease (ALAT/ASAT > 2 x upper normal limit)
- •Diabetic nephropathy (s-creatinine > 130 µM or albuminuria)
- •Proliferative diabetic retinopathy (anamnestic)
- •Severe arteriosclerosis or heart failure (NYHA group III or IV)
- •treatment with medication not applicable to pause for 12 hours
- •C-peptide increase after 50 g iv arginine
研究组 & 干预措施
hypoglycemia
Experimental
Hypoglycemic clamping
干预措施: GLP-1 (Other)
结局指标
主要结局
plasma glucagon area under curve values
时间窗: approx. 15 minutes intervals, time 0 to 120 min
次要结局
- plasma gut hormones and nutrients (absolute, incremental and area under curve values)(approx. 15 minutes intervals, time 0 to 120 min)
研究者
Mikkel Christensen
principal investigator
University Hospital, Gentofte, Copenhagen
研究点 (2)
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