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Clinical Trials/NCT05408182
NCT05408182
Unknown
Not Applicable

Feasibility and Outcomes of an Early Discharge Protocol for Robotic Colorectal Surgery (eRCS): a Prospective Observational Study Open to International Collaboration

Ospedale di Camposampiero1 site in 1 country100 target enrollmentJune 1, 2022

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Colorectal Cancer
Sponsor
Ospedale di Camposampiero
Enrollment
100
Locations
1
Primary Endpoint
Days of hospitalization
Last Updated
3 years ago

Overview

Brief Summary

The enhanced recovery after surgery (ERAS) scheme has improved recovery of patients by addressing the surgical stress and enabling a proactive perioperative care which has proven to decrease postoperative complications and reduce hospital stay. ERAS had a major beneficial effect in open colorectal surgery, while in laparoscopic surgery the additional benefit was somewhat less. Also, current literature is not clear if ERAS can improve operative outcomes of robotic colorectal surgery.

Starting from the already proven ERAS protocol, we aim to build a selective enhanced recovery scheme and a standardized early follow-up pathway enabling early safe discharge of low-risk patients after robotic colorectal surgery. This observational study will also design and assess the feasibility and clinical outcomes of an Early discharge Colorectal Surgery (eRCS) protocol which may be used to discharge patients in postoperative day 1 after robotic colorectal resections through close virtual and outpatient follow-up.

Detailed Description

This is a prospective observational study open to collaboration with international centers with expertise in robotic colorectal surgery. The cohort will include adult patients, categorized as low risk based on the inclusion criteria, which will undergo elective colorectal surgery under the governance of ERAS to enable early discharge. Patient will be followed-up clinically through pain scores, mobility scores, satisfaction and postoperative outcomes (e.g., surgical site infections, leaks, ileus, readmissions) to assess their recovery within the first 30 days postoperatively. The subgroup of patients which will be discharged on postoperative day 1 (POD 1) will form the 24h surgery group. These patients will also be closely followed-up virtually and through the outpatient department for blood samples and clinical examination. All data on patients including follow-up data will be recorded in an encrypted Excel database. Patient will be followed-up according to the above plan up to 30 days postoperatively, when they will be asked to fill in a questionnaire to assess patient reported experience (VAS score, mobility score and satisfaction rate). Postoperative complications and readmissions will be recorded. Main outcomes: * Postoperative day of discharge (early 1, intermediate 2, standard 3-5) * Patient reported outcomes: pain score (VAS), mobility score, nausea score, food tolerance score, satisfaction rate during admission, on day of discharge, on days 2, 4 and 7 for patient discharged on POD 1 and for all patients at POD 30 * Postoperative complications: surgical site infection, urinary infection, other source of sepsis, ileus, intraabdominal sepsis, anastomotic leak, cardiovascular complications, respiratory complications * Readmission rate, reintervention rate

Registry
clinicaltrials.gov
Start Date
June 1, 2022
End Date
January 1, 2023
Last Updated
3 years ago
Study Type
Observational
Sex
All

Investigators

Sponsor
Ospedale di Camposampiero
Responsible Party
Principal Investigator
Principal Investigator

Stefan Morarasu

Principal Investigator

Ospedale di Camposampiero

Eligibility Criteria

Inclusion Criteria

  • Age less than 75yo
  • ASA grade I and II
  • Not on anticoagulation
  • Elective colorectal resections
  • Does not require stoma
  • No intraoperative complications (surgical team happy with procedure)
  • Patient/Caregiver thoroughly counselled about the aim and each step of the protocol (for patients which will be discharged on POD 1)
  • Patient/Caregiver understands what to expect and knows how to manage possible issues (for patients which will be discharged on POD 1)
  • Patient/Caregiver has a direct line to the Nurse Practitioner/Surgical team member (for patients which will be discharged on POD 1)
  • Able to attend virtual and clinic follow-up in the first 10 days postoperatively (transport to hospital available - for patients which will be discharged on POD 1)

Exclusion Criteria

  • Age more than 75yo
  • ASA grade III
  • Patient on anticoagulation
  • Emergency surgery
  • Requires stoma
  • Intraoperative complications: iatrogenic injuries, significant bleeding, anaesthetic issues, new significant pathology encountered, complicated procedure, conversion to open surgery
  • Patient/Caregiver refuses early discharge
  • Caregiver not available to support patient at home (for patients which will be discharged on POD 1)
  • Cannot attend virtual or/and clinical follow-up if discharged on POD 1

Outcomes

Primary Outcomes

Days of hospitalization

Time Frame: 30 days

The length of stay in hospital will be recorded in number of days

Postoperative pain score

Time Frame: 30 days

Level of postoperative pain will be recorded through the Visual Assessment Scale (VAS). Patient will score level of pain from 1 (no pain) to 10 (worst pain ever felt). Pain will be recorded on postoperative days 1, 2, 3, 5, 7 and 30. Pain score will be measured at rest and when patient is mobilizing.

Secondary Outcomes

  • Readmission rate(30 days)
  • Mobility score(30 days)
  • Post discharge satisfaction(30 days)
  • Overall Morbidity(30 days)

Study Sites (1)

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