Comparative trial of two topical preparations in palmoplantar psoriasis

Phase 4

Not yet recruiting

• Conditions: Other psoriasis,

• Registration Number: CTRI/2019/08/020569
• Lead Sponsor: KPC Medical College and Hospital

Brief Summary

**Palmoplantar psoriasis is a localisedform of psoriasis which accounts for 3-4% of all psoriasis cases and producessignificant functional and social disability. It is a chronic recurring diseasewhich may exist in the absence of psoriasis lesions in other parts of the body.So, a randomised ,double-blind comparative trial is being planned in the OutPatient Department of Department of Dermatology in  KPC Medical College and Hospital, Jadavpur, tocompare the effectiveness  and safety oftopical Methotrexate 1%gel with urea containing emollient  versus  topical Clobetasol propionate 0.05% ointment withurea containing emollient in mild to moderate palmoplantar psoriasis.**

**In palmoplantar psoriasis, emollientsare used in conjunction with topical therapies provide a promising synergisticremedy. Application of emollients hinders water evaporation from skin, increasinghydration in stratum corneum and consequently reducing scaling and erythemaassociated with psoriasis. Due to their therapeutic effects that improve patientcomfort, emollients are used as an adjunct in topical therapies.**

**Screening is to be done afterobtaining written consent. Eligible patients will be randomised into group Aand B, and provided with respective medications in both groups. As there is nosignificant comparative study  betweentopical Methotrexate 1% gel and topical Clobetasol propionate 0.05% ointment,we intend to compare their effectiveness and safety in mild to moderatepalmoplantar psoriasis.**

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2019-02-08
• Study Start: 2019-08-19

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Males and females aged 18 to 80 years, with mild to moderate palmoplantar psoriasis.

Exclusion Criteria

Pregnant and nursing females Patients with Diabetes, malignancy, hepatic and renal dysfunction History of hypersensitivity to any drug Those previously treated for psoriasis in last 3 months Patients not willing to comply with protocol requirements.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of lesions	Week 0,2,4,6,8,10,12
Erythema	Week 0,2,4,6,8,10,12
Scaling	Week 0,2,4,6,8,10,12
PASI score	Week 0,2,4,6,8,10,12

Secondary Outcome Measures

Name	Time	Method
Quality of Life (DLQI)	Week 0,2,4,6,8,10,12

Trial Locations

Locations (1)

KPC Medical College and Hospital; 🇮🇳 Kolkata, WEST BENGAL, India

KPC Medical College and Hospital

🇮🇳Kolkata, WEST BENGAL, India

PRASUN KUMAR GHOSH

Principal investigator

9073860336

prasunkumarg@gmail.com