Evaluation of Mitochondrial Dysfunction in Severe Burn and Trauma Patients
- Conditions
- BurnsTrauma
- Registration Number
- NCT01812941
- Lead Sponsor
- University of South Alabama
- Brief Summary
The purpose of this project is to evaluate the level of mitochondrial dysfunction several patient populations: Burn, trauma, and control group of healthy volunteers.
Study hypothesis: Increased plasma concentrations of a newly discovered inflammatory mediated, called mtDNA DAMPS associated with the occurrence of multi-organ dysfunction syndrome in severly injured patients.
As the severity of a burn injury or trauma injury increase, so will systemic mitochondrial dysfunction.
- Detailed Description
Increased plasma concentrations of a newly discovered inflammatory mediated, called mtDNA DAMPS associated with the occurrence of multi-organ dysfunction syndrome in severly injured patients.
A normal healthy sub-population will be used as a control.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
- Burn injury must be less than 24 hours old at time of initial sampling
- Burn must be 2nd or 3rd degree and at least 10% TBSA
- ISS (injury severity score) > 15
- Burn injury/trauma injury > than 24hours old at time of initial sampling
- Burn < 10% total body surface area.
- Evidence of active infection on admission in the burn subjects.
- < 19 years of age and > 70 years
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- FACTORIAL
- Primary Outcome Measures
Name Time Method Plasma mtDNA DAMPs concentration approximately 1 year to assess outcome measure Plasma mtDNA DAMPs concentration
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of South Alabama Medical Center
🇺🇸Mobile, Alabama, United States