Evaluation of Mitochondrial Dysfunction in Severe Burn and Trauma Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Burns
- Sponsor
- University of South Alabama
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Plasma mtDNA DAMPs concentration
- Last Updated
- 4 years ago
Overview
Brief Summary
The purpose of this project is to evaluate the level of mitochondrial dysfunction several patient populations: Burn, trauma, and control group of healthy volunteers.
Study hypothesis: Increased plasma concentrations of a newly discovered inflammatory mediated, called mtDNA DAMPS associated with the occurrence of multi-organ dysfunction syndrome in severly injured patients.
As the severity of a burn injury or trauma injury increase, so will systemic mitochondrial dysfunction.
Detailed Description
Increased plasma concentrations of a newly discovered inflammatory mediated, called mtDNA DAMPS associated with the occurrence of multi-organ dysfunction syndrome in severly injured patients. A normal healthy sub-population will be used as a control.
Investigators
Jon Simmons
Principal investigator
University of South Alabama
Eligibility Criteria
Inclusion Criteria
- •Burn injury must be less than 24 hours old at time of initial sampling
- •Burn must be 2nd or 3rd degree and at least 10% TBSA
- •ISS (injury severity score) \> 15
Exclusion Criteria
- •Burn injury/trauma injury \> than 24hours old at time of initial sampling
- •Burn \< 10% total body surface area.
- •Evidence of active infection on admission in the burn subjects.
- •\< 19 years of age and \> 70 years
Outcomes
Primary Outcomes
Plasma mtDNA DAMPs concentration
Time Frame: approximately 1 year to assess outcome measure
Plasma mtDNA DAMPs concentration