Evaluation of Mitochondrial Dysfunction in Severe Burn and Trauma Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Plasma mtDNA DAMPs concentration
研究概览
简要总结
The purpose of this project is to evaluate the level of mitochondrial dysfunction several patient populations: Burn, trauma, and control group of healthy volunteers.
Study hypothesis: Increased plasma concentrations of a newly discovered inflammatory mediated, called mtDNA DAMPS associated with the occurrence of multi-organ dysfunction syndrome in severly injured patients.
As the severity of a burn injury or trauma injury increase, so will systemic mitochondrial dysfunction.
详细描述
Increased plasma concentrations of a newly discovered inflammatory mediated, called mtDNA DAMPS associated with the occurrence of multi-organ dysfunction syndrome in severly injured patients.
A normal healthy sub-population will be used as a control.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Factorial
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Burn injury must be less than 24 hours old at time of initial sampling
- •Burn must be 2nd or 3rd degree and at least 10% TBSA
- •ISS (injury severity score) > 15
排除标准
- •Burn injury/trauma injury > than 24hours old at time of initial sampling
- •Burn < 10% total body surface area.
- •Evidence of active infection on admission in the burn subjects.
- •< 19 years of age and > 70 years
研究组 & 干预措施
Burn: blood collection
Procedure: Blood draws as the intervention.
干预措施: Burn: blood collection (Other)
trauma: blood collection
blood to be collected at different time intervals. Blood draw as the intervention
干预措施: trauma: blood collection (Other)
healthy volunteers: blood collection
Blood draws as the intervention
干预措施: healthy volunteers: blood collection (Other)
结局指标
主要结局
Plasma mtDNA DAMPs concentration
时间窗: approximately 1 year to assess outcome measure
Plasma mtDNA DAMPs concentration
次要结局
未报告次要终点
研究者
Jon Simmons
Principal investigator
University of South Alabama