Nutritional Strategies After Muscle Strain Injuries
- Conditions
- Muscle Strain, Multiple Sites
- Interventions
- Dietary Supplement: Protein supplementationDietary Supplement: Carbohydrate supplementationProcedure: Active rehabilitation
- Registration Number
- NCT04100161
- Lead Sponsor
- Bispebjerg Hospital
- Brief Summary
Muscle strain injuries are a particularly frequent type of sports injury in soccer, athletics, badminton/ tennis and cross-fit fitness, thereby affecting a broad range of popular leisure time activities. Depending on severity, sports-active individuals may experience long-term functional impairment and pain. Additionally, individuals having sustained one strain injury have a substantially increased risk of injuring the same muscle again. Strain injuries lead to long-term, potentially permanent, loss of muscle mass, thereby weakening the muscle. Muscle atrophy is likely a major factor in the high re-injury risk. Further, strain injuries are associated with a long-term inflammatory response.
In the current study, the investigators seek to study interventions to prevent the loss of muscle mass and elaborate on strategies to address the prolonged inflammation observed at the site of the injured muscle.
The primary aim of this study is to investigate the effect of protein supplementation on the reduction of muscle atrophy following a severe muscle strain injury in comparison to a carbohydrate supplement. As a second purpose, this study aims to elaborate on findings of prolonged inflammation intra-/ intermuscular by large-scale protein analysis and the characterization of cells active at the site of injury.
The study includes the following hypotheses:
1. Protein supplementation administered in combination with a gradually increasing loading regime (rehabilitation with weekly progression in load/ intensity) will be effective in reducing the injury-related loss of muscle mass.
2. The environment at the site of injury is not only pro-inflammatory, but contains proteins associated with proteolysis.
3. Cells belonging to the group of fibro-adipogenic progenitors will be accumulating intra- and inter-muscularly.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 50
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Protein supplementation Protein supplementation 20g protein supplementation twice daily for 3 months Protein supplementation Active rehabilitation 20g protein supplementation twice daily for 3 months Carbohydrate supplementation Active rehabilitation 20g maltodextrin supplementation twice daily for 3 months Carbohydrate supplementation Carbohydrate supplementation 20g maltodextrin supplementation twice daily for 3 months
- Primary Outcome Measures
Name Time Method Muscle volume 3 months post injury Change in muscle volume in the injured muscle comparing immediate post injury scan with 3 months post scan plus comparison of change with healthy, contralateral muscle over the same time span.
- Secondary Outcome Measures
Name Time Method Muscle volume 12 months post injury Change in muscle volume in the injured muscle comparing immediate post injury scan with 12 months post scan plus comparison of change with healthy, contralateral muscle over the same time span.
Fat infiltration 12 months post injury Assessment of fat content in the injured muscle comparing immediate post injury scan with 12 months post scan plus comparison of change with healthy, contralateral muscle over same time range
Ultrasound images 12 months post injury Fascicle length measurement, pennation angle, mechanical properties of the muscle (- tendon unit) in the injured and healthy, contralateral muscle
Isokinetic muscle strength 12 months post injury Change in muscle strength in the injured leg compared to muscle strength in healthy, contralateral muscle
Injury screening Questionnaire 12 months post Assessment of subjective symptoms and pain during sports and daily activities
Assessment injury exudate <1 week post injury -12 weeks post injury Assessment and characterization of cells and soluble factors released after a strain injury into the intra-/ intermuscular space
Trial Locations
- Locations (1)
Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Nielsine Nielsen Vej 11, Building 8
🇩🇰Copenhagen, Denmark