Lymphatic Function in Patients With Secondary Tricuspid Valve Regurgitation - An Unknown Collaborator in a System Under Pressure
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Aarhus
- Enrollment
- 18
- Locations
- 1
- Primary Endpoint
- Thoracic duct volume (cubic centimetres)
Study Overview
Brief Summary
The study will examine the lymphatic functional and morphological status in patients with moderate tricuspid valve regurgitation compared to healthy age and gender-matched controls.
The study will use t2 weighted MRI, Near-infrared fluorescence imaging, and plethysmography to examine the above-mentioned question.
Detailed Description
The study will examine the lymphatic functional and morphological status in patients with moderate tricuspid valve regurgitation compared to healthy age and gender-matched controls.
Subjects will be examined at one occasion using t2-weighted MRIs to evaluated lymphatic anatomy and Near-infrared fluorescence imaging for evaluation of superficial peripheral lymphatic function. Finally, the capillary filtration rate will be estimated using plethysmography.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Thoracic duct volume (cubic centimetres)
Time Frame: 30 minutes
Based on MRI, the thoracic duct will be rendered and measured with regards to volume.
Thoracic duct tortuosity (centimeters/centimeters)
Time Frame: 20 minutes
Based on MRI, the thoracic duct will be rendered and measured with regards to tortuosity (full length/straight length)
Excess fluid (yes/no)
Time Frame: 40 minutes
Based on MRI, the existence of excess fluid in the pericardial, thoracic and abdominal cavity will be accessed.
Peripheral lymphatic velocity (centimeters/second)
Time Frame: 1 hour
Peripheral lymphatic fluid velocity (centimeters/second) will be calculated based upon NIRF sequences.
Peripheral lymphatic frequency (contractions/minute)
Time Frame: 1 hour 30 minutes
Peripheral lymphatic contraction frequency (contractions/minute) will be calculated based upon NIRF sequences.
Secondary Outcomes
- Capillary filtration(2 hours)