Lymphatic Function in Patients With Secondary Tricuspid Valve Regurgitation - An Unknown Collaborator in a System Under Pressure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- Thoracic duct volume (cubic centimetres)
研究概览
简要总结
The study will examine the lymphatic functional and morphological status in patients with moderate tricuspid valve regurgitation compared to healthy age and gender-matched controls.
The study will use t2 weighted MRI, Near-infrared fluorescence imaging, and plethysmography to examine the above-mentioned question.
详细描述
The study will examine the lymphatic functional and morphological status in patients with moderate tricuspid valve regurgitation compared to healthy age and gender-matched controls.
Subjects will be examined at one occasion using t2-weighted MRIs to evaluated lymphatic anatomy and Near-infrared fluorescence imaging for evaluation of superficial peripheral lymphatic function. Finally, the capillary filtration rate will be estimated using plethysmography.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Thoracic duct volume (cubic centimetres)
时间窗: 30 minutes
Based on MRI, the thoracic duct will be rendered and measured with regards to volume.
Thoracic duct tortuosity (centimeters/centimeters)
时间窗: 20 minutes
Based on MRI, the thoracic duct will be rendered and measured with regards to tortuosity (full length/straight length)
Excess fluid (yes/no)
时间窗: 40 minutes
Based on MRI, the existence of excess fluid in the pericardial, thoracic and abdominal cavity will be accessed.
Peripheral lymphatic velocity (centimeters/second)
时间窗: 1 hour
Peripheral lymphatic fluid velocity (centimeters/second) will be calculated based upon NIRF sequences.
Peripheral lymphatic frequency (contractions/minute)
时间窗: 1 hour 30 minutes
Peripheral lymphatic contraction frequency (contractions/minute) will be calculated based upon NIRF sequences.
次要结局
- Capillary filtration(2 hours)