Lymphatic Function in Patients With Secondary Tricuspid Valve Regurgitation - An Unknown Collaborator in a System Under Pressure
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Lymphatic Insufficiency
- Sponsor
- University of Aarhus
- Enrollment
- 18
- Locations
- 1
- Primary Endpoint
- Thoracic duct volume (cubic centimetres)
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
The study will examine the lymphatic functional and morphological status in patients with moderate tricuspid valve regurgitation compared to healthy age and gender-matched controls.
The study will use t2 weighted MRI, Near-infrared fluorescence imaging, and plethysmography to examine the above-mentioned question.
Detailed Description
The study will examine the lymphatic functional and morphological status in patients with moderate tricuspid valve regurgitation compared to healthy age and gender-matched controls. Subjects will be examined at one occasion using t2-weighted MRIs to evaluated lymphatic anatomy and Near-infrared fluorescence imaging for evaluation of superficial peripheral lymphatic function. Finally, the capillary filtration rate will be estimated using plethysmography.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Thoracic duct volume (cubic centimetres)
Time Frame: 30 minutes
Based on MRI, the thoracic duct will be rendered and measured with regards to volume.
Thoracic duct tortuosity (centimeters/centimeters)
Time Frame: 20 minutes
Based on MRI, the thoracic duct will be rendered and measured with regards to tortuosity (full length/straight length)
Excess fluid (yes/no)
Time Frame: 40 minutes
Based on MRI, the existence of excess fluid in the pericardial, thoracic and abdominal cavity will be accessed.
Peripheral lymphatic velocity (centimeters/second)
Time Frame: 1 hour
Peripheral lymphatic fluid velocity (centimeters/second) will be calculated based upon NIRF sequences.
Peripheral lymphatic frequency (contractions/minute)
Time Frame: 1 hour 30 minutes
Peripheral lymphatic contraction frequency (contractions/minute) will be calculated based upon NIRF sequences.
Secondary Outcomes
- Capillary filtration(2 hours)