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临床试验/NCT02566213
NCT02566213Unknown不适用

Human Fine-motor-skills in Weightlessness: Comparison of a Laboratory and an Everyday-like Context

University Hospital, Caen1 个研究点 分布在 1 个国家目标入组 18 人开始时间: 2010年10月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
入组人数
18
试验地点
1
主要终点
Gravity induced change in movement time (ms)

研究概览

简要总结

The human performance during weightlessness was tested in a multiplicity of laboratory experiments during parabolic flights and in space. It is therefore known that human fine motor skills as grasping are affected by the impact of changing gravity levels. However, because everyday life movements differ in several aspects from those done in an experimental lab situation, investigators do not know until know if this kind of movements is altered in the same extend.

Fine motor skills seem to depend on the context in which they are made. Thus, the performance in weightlessness during everyday life could substantially differ from the results given by previous laboratory studies.

This assumption will be tested in the present project, with subjects executing one and the same grasping movement in two different contexts, both in normal gravity conditions and in weightlessness. To that end, the investigators developed a new method which allows comparing the same grasping movements under different conditions.

详细描述

Investigations description Subjects sit at a table in front of a 15" computer screen, a centrally located joystick and a sliding lever on the right side. All devices are fixed to the table.

The subjects hand is fitted with six adhesive reflexive markers so that hand movements can be registered from above by two MX-F20 Vicon-Cameras, attached to a table-fixed metal frame. Lever forces are registered by an ATI Nano17 force transducers, lever fore-aft position by an inductive encoder, and eye position by an eye tracker (Tobii T60).

Subjects will perform two different tasks, one representing a typical laboratory (L), one an everyday-like task (E). In task L, a visual stimulus on the screen will prompt subjects to release the joystick, grasp the lever, move it forwards and back, and then return their hand to the joystick. In task E, subjects will use the joystick in a computer game ("spider chasing") and occasionally release the joystick, grasp the lever, move it forwards and back in order to collect a reward, and then return their hand to the joystick. In both tasks the visual stimuli are accompanied with acoustic signals. To hear these signals during the flight procedure, subjects are equipped with ear-phones, plugged into a laptop.

In one 20 second microgravity episode, task L will be performed five times or task E twice. The investigator starts each task with a click on the keyboard and it stops automatically after 20sec.

Control data will be registered from each subject for the same length of time during level flight at 1g.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Basic Science
盲法
None

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者
是

入选标准

  • •healthy volunteers (men or women),
  • •aged from 18 to 65,
  • •right handed,
  • •affiliated to a Social Security system and, for non-French resident, holding an European Health Insurance Card (EHIC)
  • •who accept to take part in the study,
  • •who have given their written stated consent,
  • •who have passed a medical examination similar to a standard aviation medical examination for private pilot aptitude. There will be no additional test performed for subject selection.

排除标准

  • •person who took part in a previous biomedical research protocol, of which exclusion period is not terminated,
  • •pregnant women.

研究组 & 干预措施

Motor skills measurements

Other

干预措施: Parabolic flight (Other)

Motor skills measurements

Other

干预措施: Motor skills measurements (Other)

结局指标

主要结局

Gravity induced change in movement time (ms)

时间窗: baseline

Measured by 3D videocamera, it is the time between the beginning of the hand movement and the contact of the hand on the object

Gravity induced change in peak velocity of the hand (deg/sec)

时间窗: baseline

Measured by 3D videocamera

Gravity induced change in the maximum grip aperture of the hand (mm)

时间窗: baseline

Measured by 3D videocamera. It is the maximum distance between the first and the fifth digit before hand grasps the object

Gravity induced change in the initial force applied by the hand on the grasped object (newton)

时间窗: baseline

Force measured by a strain gauge

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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