Effect of Intensive Cognitive Rehabilitation on Cognitive, Motor, and Language Functional Networks in Subacute Stroke Patient

Not Applicable

Withdrawn

• Conditions: Stroke
• Interventions: Procedure: Cognitive rehabilitation

• Registration Number: NCT05254964
• Lead Sponsor: Samsung Medical Center

Brief Summary

Altered brain networks, including cognitive, motor, and language networks, are investigated by intensive cognitive rehabilitation in subacute stroke patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-02-01
• Study First Submitted: 2022-02-09
• Study First Submitted QC: 2022-02-21
• Study First Posted: 2022-02-24
• Primary Completion: 2023-02-28
• Study Completion: 2023-02-28
• Status Verified: 2023-03
• Last Update Submitted: 2023-03-05
• Last Update Posted: 2023-03-07

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Patients aged 19 to 80 years
• Patients with subacute stroke within 2 weeks of onset
• First-ever stroke
• Supratentorial stroke
• Less than 8 SAFE (shoulder abduction, finger extension) points
• Less than 35 FMA Upper scores
• MEP (motor evoked potential) negative
• Not more than 24 K-MMSE (Korean Mini-Mental State Examination) score

Exclusion Criteria

• Difficult to communicate due to severe language impairment.
• Accompanied by an existing serious neurogenic disease
• Existing significant psychiatric disorders such as major schizophrenia, bipolar disorder
• If there are difficulties in conducting the research
• Any patients who are judged by the investigator to be difficult to participate in this study
• Patients with contraindicated MRI scans

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Intensive cognitive rehabilitation group	Cognitive rehabilitation	Participants receive intensive cognitive rehabilitation for 20 hours for 4 weeks.

Primary Outcome Measures

Name	Time	Method
Strength of connectivity in brain network obtained from MRI neuroimaging data	Change in strength of connectivity after intensive cognitive rehabilitation for 4 weeks	Participants' MRI neuroimaging data are acquired at pre- and post-intervention. Brain network can be constructed using MRI neuroimaging data, and strength of connectivity can be calculated in the brain network. Strength of connectivity has a value between -1 and 1.

Trial Locations

Locations (1)

Samsung Medical Center; 🇰🇷 Seoul, Korea, Republic of