Effect of exclusion of bacteremia on antibiotic treatment
Not Applicable
Completed
- Conditions
- Specialty: Critical care, Primary sub-specialty: Critical careUKCRC code/ Disease: Inflammatory and Immune System/ Other diseases of blood and blood-forming organs, Infection/ Bacterial, viral and other infectious agentsInfections and InfestationsInfections
- Registration Number
- ISRCTN17325124
- Lead Sponsor
- niversity College London Hospitals NHS Foundation Trust
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
1. Patient has blood culture taken in critical care unit
2. Age >18 years
3. Not palliative treatment
4. Discharge expected within 48 hours
5. Death not imminent
6. Blood culture positive <12 hours
7. Test cannot be completed on the day sample taken
Exclusion Criteria
1. Patient < 18 years of age
2. The treatment intent is palliative; the clinician is not committed to aggressive treatment
3. Treating clinician expects the patient to be discharged from the ICU on the day of evaluation (i.e. assessment for inclusion) or the following day
4. Death is deemed imminent and inevitable
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Whether the clinician’s decision on continuing antibiotic would have been affected by the test result if it had been available is assessed through clinician interviews at 24 and 48 hours.
- Secondary Outcome Measures
Name Time Method umber of defined daily doses of antibiotic that would have been saved if the clinician had decided to stop antibiotics upon receiving a negative test result is determined by reviewing the patient’s current antibiotic treatment and expected duration at 24 or 48 hours.