ISRCTN84202126已完成不适用
sing functional Magnetic Resonance Imaging to assess the impact of Mandolean training on the neural control of obesity in young people: a feasibility study for the Bristol Nutrition BR
niversity of Bristol0 个研究点目标入组 40 人开始时间: 2018年2月22日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 40
研究概览
简要总结
- 2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/30466438
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. The target population for the obese group will be obese adolescents and young adults aged 11 years or above with a
- •BMI >/= 95th percentile (definition of obesity in National Child Measurement Programme)
- •2. The target population for the MC4R group will be adolescents and adults with obesity confirmed to be due to MC4R mutation (Cambridge Genetics of Simple Obesity Study)
- •3. The target population for the control group will be normal-weight adolescents and young adults aged 11 years or above
排除标准
- •1. Children and adults with learning difficulties, visual or hearing difficulties, dysmorphic features suggesting other
- •syndromes such as Prader?Willi
- •2. Children and adults with endocrine disorders such as hypothyroidism
- •3. Children and adults with iatrogenic causes of obesity ? cranial surgery, anticonvulsant therapy
- •4. Children and adults whose first language is not English
- •5. Patients for whom it would not be safe to enter the MR environment. Contraindications for participation are:
- •5.1. Metal implants (internal defibrillator, cochlear implant, artificial heart valves, implanted drug infusion ports, metal
- •dental work if not removable, cardiac pacemaker, artificial limbs or metallic joint prostheses, metal pins, screws plates
- •or surgical staples, intrauterine device)
- •5.2. Tattoos with metallic ink or unremovable body piercing which might be attracted to the magnet used during fMRI
- •scanning and to avoid image distortion
- •5.3. Pregnancy, to avoid harm to the foetus
- •5.4. History of neurological disease, traumatic brain injury, mental illness
- •5.5. Claustrophobia, to avoid including participants with brain abnormalities or at risk of anxiety, in particular, anxiety
- •related to being in enclosed places
- •5.6. Medical health problems requiring medication, to avoid disruption to brain function and responsiveness to glucose
- •or test meals
- •5.7. Weight above 152kg due to the limits of the scanner bed, and girth of less than 210cm in order to fit inside the 70cm
- •diameter bore of the scanner
- •5.8. Vegetarian or vegan, so that the images of food shown in the cue-reactivity task are not aversive to participants
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