Acute Effects of Cinacalcet on Arterial Stiffness and Ventricular Function in Hemodialysis Patients
- Registration Number
- NCT01250405
- Lead Sponsor
- Laval University
- Brief Summary
The primary objective is to determine whether reduction of serum calcium concentration by cinacalcet leads to reduction of mean blood pressure adjusted c-fPWV. The secondary objectives are to study the effects of calcium reduction on 1) carotid-radial PWV (c-rPWV), 2) common carotid artery (CCA) biomechanics, 3) pulse wave profile and cardiac function.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 23
Inclusion Criteria
- chronic (> 3 months) hemodialysis population of > 18 years old
- PTH > 300 ng/L
- corrected Ca > 2.10 mmol/L
- stable hypertensive drugs (> 1 month)
- stable doses of phosphate binders and dialysis calcium concentration
- palpable femoral pulse
- systolic BP of 90-180 mmHg
- expected survival of > 6 months
Exclusion Criteria
- hemodialysis > 3 years
- acute infection
- history of myocardial infarction or stroke within the past 3 months
- inability to consent
- intolerance to cinacalcet
- inadequate birth control
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Placebo Placebo - Cinacalcet Cinacalcet -
- Primary Outcome Measures
Name Time Method Arterial stiffness Arterial stiffness with be measured after 1 week with placebo and after 1 week with cinacalcet
- Secondary Outcome Measures
Name Time Method Ventricular function Ventricular function with be measured after 1 week with placebo and after 1 week with cinacalcet
Trial Locations
- Locations (1)
Karine Marquis
🇨🇦Québec, Quebec, Canada