Perfusion and Dual Energy Computer Tomography in Hepatocellular Carcinoma

Not Applicable

• Conditions: Hepatocellular Carcinoma
• Interventions: Radiation: perfusion Computed Tomography

• Registration Number: NCT03754192
• Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Brief Summary

The aim of this study is to evaluate the hepatic perfusion computer tomography and dual energy computer tomography in the assessment of tumor characterization of Hepatocellular carcinoma in patients with resectable Hepatocellular carcinoma by comparing the quantitative parameters computer tomography obtained with the pathological data of the surgical specimens.

Detailed Description

Dual-energy computer tomography and perfusion computer tomography (General Electric revolution Hight definition Gemstone™ Spectral Imaging) will be performed in all patients. Iodine concentration and quantitative perfusion parameters of the Hepatocellular carcinoma and surrounding liver parenchyma data will be compared with the pathological results.

Study Timeline

• Study First Submitted: 2018-11-14
• Study First Submitted QC: 2018-11-26
• Study First Posted: 2018-11-27
• Study Start: 2019-01-30
• Status Verified: 2020-08
• Last Update Submitted: 2020-08-31
• Last Update Posted: 2020-09-01
• Primary Completion: 2020-12-30
• Study Completion: 2020-12-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• A diagnosis of Hepatocellular carcinoma made according to the guidelines of the American Association for the study of the Liver
• Affiliation to a national health insurance
• An indication for hepatic resection during the decision-making stage
• A request for a pre-operative Computer Tomography in our radiology unit
• An affiliation to a social security
• Informed consent given by the patient

Exclusion Criteria

• Previous treatments of Hepatocellular carcinoma (medicated or surgical)
• Patient under tutorship or curatorship
• Pregnant or lactating woman

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
perfusion computed tomography	perfusion Computed Tomography	Will be realsed before liver surgery

Primary Outcome Measures

Name	Time	Method
Pefusion parameters	5 minutes	correlation between pre-operative imaging data and histological data of Hepatocellular carcinoma

Secondary Outcome Measures

Name	Time	Method
Pathological examination	1 month	Compare data obtained in perfusion computer tomography to the imaging data and to the Histological differentiation grades

Trial Locations

Locations (1)

CHU Paul Brousse; 🇫🇷 Villejuif, France