NL-OMON50303招募中不适用
Resistant HYpertension: MEasure to ReaCh Targets - RHYME-RCT
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 392
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •* Resistant hypertension: office blood pressure > 140 AND/OR 90 mmHg and 24h
- •ABPM (ambulatory blood pressure measurement) daytime blood pressure >135 AND/OR
- •85 mmHg despite a medication regimen of antihypertensive drugs from at least
- •three classes including a diuretic or the use of at least four antihypertensive
- •drugs from different classes
- •* Secondary forms of hypertension have been excluded according to local
- •guidelines or a secondary form of hypertension has been established or is
- •likely but chosen treatment is drug therapy (for instance primary
- •hyperaldosteronism, renovascular hypertension)
- •* Use of at least two drugs for which DBS-analysis is available (angiotensin
- •converting enzyme inhibitors: enalapril and perindopril; angiotensin II
- •receptor blockers: candesartan, irbesartan, losartan, telmisartan, valsartan;
- •diuretics: bumetanide, chlorthalidone, hydrochlorothiazide and spironolactone;
- •calcium channel blockers: amlodipine, barnidipine, lercanidipine, and
- •nifedipine; beta blocker: metoprolol; alpha blocker: doxazosine).
- •* Age * 18 years
- •* Providing informed consent after reading patient information
排除标准
- •* Not providing informed consent or not capable of giving informed consent
- •* End-stage renal disease (eGFR<15 ml/min)
- •* Insufficient understanding of Dutch or Turkish language
研究者
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