Neuromotor Adaptation to Fatigue: Changes in Lower Extremity Proprioception in Patients With Osteoarthritis
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 20
- 主要终点
- Joint Position Sense
研究概览
简要总结
This study aims to investigate the effects of fatigue induced by isokinetic exercise on passive and active joint position sense in postmenopausal women diagnosed with knee osteoarthritis (gonarthrosis). A healthy control group matched for age and sex will also be included for comparative analysis. Participants will undergo proprioceptive assessments before and after an isokinetic fatigue protocol. We hypothesize that (1) fatigue will impair both passive and active joint position sense in patients with gonarthrosis, (2) active joint position sense will be more affected than passive sense, and (3) the deterioration in proprioception will be greater in the gonarthrosis group compared to healthy controls.
详细描述
Osteoarthritis, particularly knee osteoarthritis (gonarthrosis), is a progressive musculoskeletal disease that severely affects lower extremity functions. Proprioceptive impairments in these patients can lead to altered motor control, reduced movement accuracy, and increased risk of falls. Fatigue may exacerbate these impairments by affecting sensory feedback from muscle spindles and joint receptors, which is critical for joint stability and motor control. In postmenopausal women, hormonal changes further compound muscle weakness and joint instability, highlighting the clinical importance of understanding proprioceptive changes following fatigue.
This experimental study will involve two groups: postmenopausal women with gonarthrosis and age-matched healthy controls. Participants will undergo an isokinetic fatigue protocol followed by assessments of passive and active joint position sense being more vulnerable. Understanding these changes will contribute to developing rehabilitation strategies focusing on proprioception and fatigue management.
We expect that isokinetic fatigue will impair proprioception, with active joint position
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Female, aged 50-65
- •Postmenopausal
- •Grade 2-3 knee osteoarthritis (Kellgren-Lawrence Scale) for OA group
- •No lower extremity surgery in the last 6 months
- •No neuromuscular or orthopedic condition affecting the lower extremities
排除标准
- •Severe balance disorders or vestibular disease
- •Bilateral knee prosthesis or severe osteoporosis
- •Lower extremity musculoskeletal injury in the last 6 months
研究组 & 干预措施
Healthy Control
Age- and sex-matched postmenopausal women without knee pathology. Participants will perform the same passive and active joint position sense tests as the gonarthrosis group, before and after a control fatigue protocol using the Biodex system.
干预措施: Fatigue Protocol + Joint Position Sense Testing (Diagnostic Test)
Gonarthrosis Group
Postmenopausal women aged 50-65 with Kellgren-Lawrence Grade 2-3 knee osteoarthritis.
Participants will undergo an isokinetic fatigue protocol at 180°/s using a Biodex dynamometer. Passive and active joint position sense tests will be performed before and after fatigue.
干预措施: Fatigue Protocol + Joint Position Sense Testing (Diagnostic Test)
结局指标
主要结局
Joint Position Sense
时间窗: From enrollment to the end of intervention for 10 minutes
Passive Joint Position Sense Test: The knee joint will be passively moved to 45°, then returned to the starting position. The participant will be asked to perceive and replicate the same angle passively. The difference between the perceived and actual angles will be recorded. An isokinetic dynamometer will be used during this test. Active Joint Position Sense Test: With their eyes closed, participants will be asked to actively move their knee to 45° and then return to the starting position. They will then be asked to actively reproduce the same angle. The difference between the measured and target angles will be recorded. An isokinetic dynamometer will be used during this test.
次要结局
未报告次要终点