ISRCTN21056528已完成不适用
Investigation of the anti-inflammatory effects of simvastatin in a human lipopolysaccharide induced model of acute lung injury
Belfast Health and Social Care Trust (UK)0 个研究点目标入组 30 人开始时间: 2008年6月9日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •Healthy subjects, both males and females
排除标准
- •1. Age <18 years
- •2. Creatinine kinase (CK) >5 times upper limit of normal
- •3. Known active liver disease
- •4. Alcohol abuse or abnormal liver function tests: transaminases > 3 times upper limit of normal
- •5. Renal impairment (calculated creatinine clearance less than 60 mL/minute)
- •6. History of asthma, known lactose intolerance
- •7. Participation in other trials within the past 30 days
- •8. Pregnancy, breast-feeding or women of childbearing potential not using adequate contraception;
- •9. Current treatment with statins
- •10. Known hypersensitivity to the study medication
- •11. Previous adverse reaction to statins
- •12. Concomitant use of fibrates or other lipid-lowering therapy
- •13. Concomitant use of itraconazole, ketoconazole, erythromycin, clarithromycin, telithromycin, HIV protease inhibitors, nefazodone, grapefruit juice, cyclosporine, danazol, amiodarone, verapamil or diltiazem
- •14. Consent declined
研究者
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