Skip to main content
MedPathMedPath Home
Clinical Trials/ISRCTN21056528
ISRCTN21056528
Completed
Not Applicable

Investigation of the anti-inflammatory effects of simvastatin in a human lipopolysaccharide induced model of acute lung injury

Belfast Health and Social Care Trust (UK)0 sites30 target enrollmentJune 9, 2008
Share to TwitterShare to FacebookShare to LinkedInShare to Reddit

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Not specified
Sponsor
Belfast Health and Social Care Trust (UK)
Enrollment
30
Status
Completed
Last Updated
11 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
June 9, 2008
End Date
TBD
Last Updated
11 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
Belfast Health and Social Care Trust (UK)

Eligibility Criteria

Inclusion Criteria

  • •Healthy subjects, both males and females

Exclusion Criteria

  • •1\. Age \<18 years
  • •2\. Creatinine kinase (CK) \>5 times upper limit of normal
  • •3\. Known active liver disease
  • •4\. Alcohol abuse or abnormal liver function tests: transaminases \> 3 times upper limit of normal
  • •5\. Renal impairment (calculated creatinine clearance less than 60 mL/minute)
  • •6\. History of asthma, known lactose intolerance
  • •7\. Participation in other trials within the past 30 days
  • •8\. Pregnancy, breast\-feeding or women of childbearing potential not using adequate contraception;
  • •9\. Current treatment with statins
  • •10\. Known hypersensitivity to the study medication

Outcomes

Primary Outcomes

Not specified

Similar Trials

Active, not recruiting
Phase 1
Investigation of the anti-inflammatory effects of simvastatin in a model of acute lung injury after inhalation of lipopolysaccharide by healthy volunteers - Statins in a model of acute lung injury in healthy volunteersAcute lung injury (ALI)
EUCTR2006-004396-35-GBBelfast City Hospital Trust
Not yet recruiting
Not Applicable
Anti-inflammatory and immunomodulative effects of clarithromycin for severe septic patientssevere sepsis
JPRN-UMIN000021476Inoue laboratory, Tokai University30
Recruiting
Not Applicable
Anti-inflammatory and immunomodulative effects of human recombinant thrombomodulin for severe septic patients
JPRN-UMIN000018868Inoue&#39;s Labo in Tokai University45
Active, not recruiting
Not Applicable
Verification of the anti-inflammatory effect with new PMMA dialyzer &quot;NF&quot; -CNW multicenter trialChronic renal failure
JPRN-UMIN000016567JCHO Chiba Hospital37
Active, not recruiting
Not Applicable
Evaluation of the anti-inflammatory effect of continous insulin infusion in non-diabetic patients undergoing cardia surgery - NDPatients candidate to cardiac surgeryMedDRA version: 9.1Level: SOCClassification code 10007541Term: Cardiac disorders
EUCTR2007-001481-32-ITAZIENDA OSPEDALIERA OSPEDALE POLICLINICO CONSORZIALE