Antidepressant efficacy and mechanism of add-on cognitive activation to repetitive transcranial magnetic stimulation in depressio
Not Applicable
Completed
- Conditions
- A randomized sham-controlled study
- Registration Number
- JPRN-UMIN000008421
- Lead Sponsor
- Taipei Veterans General Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 36
Inclusion Criteria
Not provided
Exclusion Criteria
Major systemic, neurological illness Substance abuse Personality disorders OCD PTSD Major psychotic disorders(e.g., Schizophrenia)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method EEG-theta (esp. frontal regions) PET-glucose metabolism: ACC and PFC Antidepressant efficacy (HAMD-17 scores)
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie cognitive activation's enhancement of rACC activity in depression trials?
How does add-on cognitive activation compare to standard antidepressants in randomized sham-controlled studies?
Which biomarkers correlate with improved antidepressant efficacy in rACC-targeted rTMS interventions?
What adverse events are associated with combined rTMS and cognitive activation in depression treatment?
Are there alternative neuromodulation strategies that synergize with cognitive therapies for depression?