Superselective Adrenal Arterial Embolization for Refractory Hypertension: A Proof-of-Concept Study
- Conditions
- Essential Hypertension
- Registration Number
- NCT06568640
- Lead Sponsor
- Second Affiliated Hospital of Nanchang University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria:<br><br> - Age > 18 years, no gender restrictions;<br><br> - Primary refractory hypertension: Taking three antihypertensive drugs, including a -<br> diuretic, with an average office systolic blood pressure =150 mmHg measured three<br> times;<br><br> - Duration of hypertension greater than 6 months;<br><br> - Standing plasma aldosterone and renin activity not below the lower limit of the<br> unit's reference range;<br><br> - Signed informed consent form.<br><br>Exclusion Criteria:<br><br> - Morning cortisol level < 4.3 µg/dL; estimated glomerular filtration rate (eGFR) < 45<br> mL/min/1.73 m²; serum potassium level > 5.5 mmol/L;<br><br> - Type 1 diabetes, uncontrolled hyperthyroidism, malignant arrhythmias, malignant<br> tumors, decompensated heart failure, severe liver dysfunction, severe hematological<br> diseases, severe obstructive sleep apnea syndrome, history of myocardial infarction,<br> syncope, cerebral hemorrhage, or cerebral infarction within the past 3 months;<br><br> - Pregnant women or those planning to conceive within the next year;<br><br> - Presence of other severe organic diseases that would make the patient unable to<br> tolerate superselective adrenal arterial embolization;<br><br> - Adrenal mass with a diameter exceeding 2 cm;<br><br> - Severe allergy to contrast agents;<br><br> - Patients enrolled or planning to participate in other clinical studies that could<br> impact the results of this study.
Not provided
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 24-hour mean systolic blood pressure
- Secondary Outcome Measures
Name Time Method Proportion of patients with non-refractory hypertension;24-hour mean diastolic blood pressure;Safety monitoring:Procedure-related complications;Safety monitoring:Adrenal-related hormones;Safety monitoring:Kidney function;Safety monitoring:Plasma electrolyte levels