Impact of Cardiac Surgery in Severe Left Endocarditis With Neurological Complications: a Multicentric,Retrospective, Propensity-score Matching Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 192
- 主要终点
- Mortality
研究概览
简要总结
Surgical delay in severe endocardits, with neurological complications, is still debated. Early surgery, if indicated, permits to avoid new embolic events, or to fix valvular damages, but can create or increase a cerebral hemorrage.
Hypothesis Cardiac surgery, as soon as possible, if indicated, would reduce mortality, in severe left endocarditis, with neurological complications.
Primary objective To assess the impact of early versus late cardiac surgery on mortality at 1 year, in patients with severe endocarditis, with neurological complications.
Primary endpoint:
- Mortality at 1 year
Secondary endpoints:
- Analyze the factors associated with neurological degradation
- Evaluate the neurological tolerance of cardiac surgery.
详细描述
Surgical delay in severe endocardits, with neurological complications, is still debated. Early surgery, if indicated, permits to avoid new embolic events, or to fix valvular damages, but can create or increase a cerebral hemorrage.
Hypothesis Cardiac surgery, as soon as possible, if indicated, would reduce mortality, in severe left endocarditis, with neurological complications.
Primary objective To assess the impact of early versus late cardiac surgery on mortality at 1 year, in patients with severe endocarditis, with neurological complications.
Primary endpoint:
- Mortality at 1 year
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Left endocarditis
- •With indication of cardiac surgery
- •Severe endocaditis (SOFA score > or = 3/16)
- •With pre operative neurological complications
排除标准
- •Age < 18
- •Right endocarditis without left endocarditis
- •No severe endocarditis (SOFA score < 3)
- •Ne pre operative neurological complications
- •Endocarditis without indication of cardiac surgery
结局指标
主要结局
Mortality
时间窗: at 1 year after the diagnosis of endocarditis
Death from any cause
次要结局
- Neurogical tolerance(At 6 months)
研究者
Dr Alexandre Gros
GROS, Alexandre, Medical Doctor, Intensive Care Unit, Principal Investigator
Gros, Alexandre, M.D.