A New Anatomical Classification of Portal Vein Location of Pancreas Tumors

Not Applicable

Completed

• Conditions: Pancreatic Neoplasm Malignant Head Primary
• Interventions: Procedure: primary repair; Procedure: segmental resection; Procedure: graft reconstruction

• Registration Number: NCT04416685
• Lead Sponsor: Sisli Hamidiye Etfal Training and Research Hospital

Brief Summary

In this retrospective study, we recorded the location of pancreatic tumors and relation/proximity to the portal vein. The surgical difficulty and requirement of additional interventions were also evaluated.

Detailed Description

Between May 2014 and October 2018, all patients who underwent PD procedure were retrospectively reviewed. This retrospective cohort study identified all consecutive patients with T3 (stage IIA to III) adenocarcinoma of the head of the pancreas, who underwent concomitant venous (PV/SMV) resection. Those patients with locally advanced tumors that were not responded to neoadjuvant therapy were excluded. The local ethical committee was approved this study.

Data collection included demographical features, tumor characteristics including the PV level of the tumor considering computed tomography results, neoadjuvant therapy, surgical data, hospital stay, morbidity and mortality.

Anatomical classification was established based on the relationship between portal confluence (PC) and tumor location (Figure I). Those tumors located superior to the PC were classified as Level I, whereas tumors on the confluence inferiorly located to PC were classified as Level II and Level III.

Study Timeline

• Study Start: 2014-05-01
• Primary Completion: 2018-10-01
• Study Completion: 2019-05-01
• Study First Submitted: 2020-05-31
• Study First Submitted QC: 2020-06-03
• Study First Posted: 2020-06-04
• Status Verified: 2022-04
• Last Update Submitted: 2022-05-05
• Last Update Posted: 2022-05-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 43

Inclusion Criteria

• This retrospective cohort study identified all consecutive patients with T3 (stage IIA to III) adenocarcinoma of the head of the pancreas, who underwent concomitant venous (PV/SMV) resection.

Exclusion Criteria

• Those patients with locally advanced tumors that were not responded to neoadjuvant therapy were excluded.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Level 1	primary repair	Those tumors located superior to the portal confluence were classified as Level I,
Level II	segmental resection	those tumors located on the confluence (involving the confluence) located on the portal confluence
Level III	segmental resection	those tumors located inferior to the portal confluence
Level 1	segmental resection	Those tumors located superior to the portal confluence were classified as Level I,
Level III	graft reconstruction	those tumors located inferior to the portal confluence
Level II	primary repair	those tumors located on the confluence (involving the confluence) located on the portal confluence

Primary Outcome Measures

Name	Time	Method
peri-operative or postoperative complication	up to one month	surgical complications observed during both operative and postoperative period

Secondary Outcome Measures

Name	Time	Method
hospital stay	up to one month	the time between the day of surgery and hospital discharge